Приказ основних података о документу
Structure-activity relationships of 3-substituted-5,5-diphenylhydantoins as potential antiproliferative and antimicrobial agents
Uticaj strukture na antiproliferativnu i antibakterijsku aktivnost 3-supstituisanih-5,5-difenilhidantoina
dc.creator | Trišović, Nemanja | |
dc.creator | Božić, Bojan | |
dc.creator | Obradović, Ana | |
dc.creator | Stefanović, Olgica | |
dc.creator | Marković, Snežana | |
dc.creator | Čomić, Ljiljana | |
dc.creator | Božić, Biljana | |
dc.creator | Ušćumlić, Gordana | |
dc.date.accessioned | 2021-03-10T11:29:16Z | |
dc.date.available | 2021-03-10T11:29:16Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1797 | |
dc.description.abstract | A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature. Their antiproliferative activities against HCT-116 human colon carcinoma cells were evaluated to determine structure-activity relationships. Almost all of the compounds exhibited statistically significant antiproliferative effects at a concentration of 100 μM, while the derivative bearing a benzyl group was active even at lower concentrations. Moreover, their in vitro antibacterial activities against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and clinical isolates of Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Enterococcus faecalis and Staphylococcus aureus were evaluated. Only the 3-isopropyl and 3-benzyl derivatives showed weak antibacterial activities against the Gram-positive bacterium E. faecalis and the Gram-negative bacteria E. coli ATCC 25922 and E. coli. | en |
dc.description.abstract | Sintetisana je serija od dvanaest 3-supstituisanih-5,5-difenilhidantoina, koja obuhvata neke od derivata čije su antikonvulzivne aktivnosti poznate u literaturi. Određena je njihova antiproliferativna aktivnost prema ćelijskoj liniji humanog karcinoma kolona, kako bi se utvrdio uticaj strukture na aktivnost. Skoro sva jedinjenja ispoljavaju antiproliferativan efekat u koncentraciji od 100 μM, dok je derivat sa benzil grupom aktivan i u nižim koncentracijama. Dodatno je određena i antibakterijska aktivnost proučavanih jedinjenja prema Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 i kliničkim izolatima Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Enterococcus faecalis i Staphylococcus aureus. 3-Izopropil i 3-benzil derivati pokazuju slabu aktivnost prema gram-pozitivnoj bakteriji E. faecalis i gram-negativnim bakterijama E. coli ATCC 25922 i E. coli. | sr |
dc.publisher | Serbian Chemical Society, Belgrade | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | phenytoin derivatives | en |
dc.subject | antiproliferative activity | en |
dc.subject | antimicrobial activity | en |
dc.subject | structure-activity relationship | en |
dc.title | Structure-activity relationships of 3-substituted-5,5-diphenylhydantoins as potential antiproliferative and antimicrobial agents | en |
dc.title | Uticaj strukture na antiproliferativnu i antibakterijsku aktivnost 3-supstituisanih-5,5-difenilhidantoina | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 1606 | |
dc.citation.issue | 12 | |
dc.citation.other | 76(12): 1597-1606 | |
dc.citation.rank | M23 | |
dc.citation.spage | 1597 | |
dc.citation.volume | 76 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/12159/0352-51391100143T.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_technorep_1797 | |
dc.identifier.scopus | 2-s2.0-84858685963 | |
dc.identifier.wos | 000298777900001 | |
dc.type.version | publishedVersion |