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Uticaj strukture na antiproliferativnu i antibakterijsku aktivnost 3-supstituisanih-5,5-difenilhidantoina

dc.creatorTrišović, Nemanja
dc.creatorBožić, Bojan
dc.creatorObradović, Ana
dc.creatorStefanović, Olgica
dc.creatorMarković, Snežana
dc.creatorČomić, Ljiljana
dc.creatorBožić, Biljana
dc.creatorUšćumlić, Gordana
dc.date.accessioned2021-03-10T11:29:16Z
dc.date.available2021-03-10T11:29:16Z
dc.date.issued2011
dc.identifier.issn0352-5139
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1797
dc.description.abstractA series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature. Their antiproliferative activities against HCT-116 human colon carcinoma cells were evaluated to determine structure-activity relationships. Almost all of the compounds exhibited statistically significant antiproliferative effects at a concentration of 100 μM, while the derivative bearing a benzyl group was active even at lower concentrations. Moreover, their in vitro antibacterial activities against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and clinical isolates of Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Enterococcus faecalis and Staphylococcus aureus were evaluated. Only the 3-isopropyl and 3-benzyl derivatives showed weak antibacterial activities against the Gram-positive bacterium E. faecalis and the Gram-negative bacteria E. coli ATCC 25922 and E. coli.en
dc.description.abstractSintetisana je serija od dvanaest 3-supstituisanih-5,5-difenilhidantoina, koja obuhvata neke od derivata čije su antikonvulzivne aktivnosti poznate u literaturi. Određena je njihova antiproliferativna aktivnost prema ćelijskoj liniji humanog karcinoma kolona, kako bi se utvrdio uticaj strukture na aktivnost. Skoro sva jedinjenja ispoljavaju antiproliferativan efekat u koncentraciji od 100 μM, dok je derivat sa benzil grupom aktivan i u nižim koncentracijama. Dodatno je određena i antibakterijska aktivnost proučavanih jedinjenja prema Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 i kliničkim izolatima Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Enterococcus faecalis i Staphylococcus aureus. 3-Izopropil i 3-benzil derivati pokazuju slabu aktivnost prema gram-pozitivnoj bakteriji E. faecalis i gram-negativnim bakterijama E. coli ATCC 25922 i E. coli.sr
dc.publisherSerbian Chemical Society, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectphenytoin derivativesen
dc.subjectantiproliferative activityen
dc.subjectantimicrobial activityen
dc.subjectstructure-activity relationshipen
dc.titleStructure-activity relationships of 3-substituted-5,5-diphenylhydantoins as potential antiproliferative and antimicrobial agentsen
dc.titleUticaj strukture na antiproliferativnu i antibakterijsku aktivnost 3-supstituisanih-5,5-difenilhidantoinasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage1606
dc.citation.issue12
dc.citation.other76(12): 1597-1606
dc.citation.rankM23
dc.citation.spage1597
dc.citation.volume76
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/12159/0352-51391100143T.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_technorep_1797
dc.identifier.scopus2-s2.0-84858685963
dc.identifier.wos000298777900001
dc.type.versionpublishedVersion


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