Structure optimization of polylactide microcapsules for controlled drug release

Abstract

The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration.