Приказ основних података о документу

dc.creatorVaštag, Đenđi
dc.creatorPerišić-Janjić, Nada
dc.creatorTomić, Jelena
dc.creatorPetrović, Slobodan
dc.date.accessioned2021-03-10T11:33:15Z
dc.date.available2021-03-10T11:33:15Z
dc.date.issued2011
dc.identifier.issn0933-4173
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1858
dc.description.abstractThe chromatographic behavior of N-cyclohexyl-N-substituted-2-phenylacetamides was investigated using reversed phase thin-layer chromatography (RP-TLC). RP-TLC was performed on a C-18 bonded phase with different aqueous eluents: water-acetone, water-acetonitrile and water dioxane. Linear relationship between retention parameters and organic modifier content in the mobile phase allows the extrapolation procedure. From results, it is evident that retention behavior of investigated compound depended on structures of substituents R. The correlation between the chromatographic lipophilic parameters (R-M(0)) and calculated log P values and several pharmacokinetics parameters such as HIA (human intestinal absorption) predictor, the plasma protein binding (PB) predictor, and partition predictor for predicting the biological activity of the blood-brain barrier (BBB) has been studied. The results show that reversed-phase R-M(0) proved to express lipophilic nature of investigated compounds as well as biological activity.en
dc.publisherAkademiai Kiado Zrt, Budapest
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.rightsrestrictedAccess
dc.sourceJPC-Journal of Planar Chromatography-Modern Tlc
dc.subjectN-cyclohexyl-N-substituted-2-phenylacetamideen
dc.subjectRP-C-18 TLCen
dc.subjectLipophilicityen
dc.titleEvaluation of the Lipophilicity and Prediction of Biological Activity of Some N-Cyclohexyl-N-Substituted-2-Phenylacetamide Derivatives Using RP-TLCen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage440
dc.citation.issue5
dc.citation.other24(5): 435-440
dc.citation.rankM23
dc.citation.spage435
dc.citation.volume24
dc.identifier.doi10.1556/JPC.24.2011.5.13
dc.identifier.scopus2-s2.0-80054926399
dc.identifier.wos000296269900014
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу