Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode
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2012
Authors
Stoiljković, Zora Ž.Avramov-Ivić, Milka
Petrović, Slobodan
Mijin, Dušan
Stevanović, Sanja
Lačnjevac, Uroš
Marinković, Aleksandar
Article (Published version)
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The oxidative behaviour of amlodipine besylate was studied. The gold electrode and Au/o-MWCNT (oxidized multi-wall carbon nanotubes) were used for determination of amlodipine besylate standard and as a content of Alopres tablet, in 0.05 M NaHCO3 and in phosphate buffer (pH=11) by cyclic voltammetry and square-wave anodic stripping voltammetry. Electrode surfaces were characterized by AFM in the presence of amlodipine and the concentrations of drugs in electrolytes were simultaneously followed by HPLC. The linear dependency of the anodic currents of amlodipine besylate as standard and in Alopres tablet vs. concentration was observed in both electrolytes, but in phosphate buffer for the higher concentrations. The peak currents obtained in all experiments are more than fifty-fold higher comparing to all previously published results concerning the glassy carbon electrode and the carbon paste electrode. The gold electrode is better catalyst for anodic oxidation of amlodipine besylate than g...lassy carbone. The results obtained with Au/o-MWCNT show lower anodic activity comparing to previously published GC/o-MWCNT. GC/o-MWCNT is better catalyst than Au/o-MWCNT under similar experimental conditions.
Keywords:
amlodipine / gold electrode / o-MWCNT / atomic force microscopySource:
International Journal of Electrochemical Science, 2012, 7, 3, 2288-2303Publisher:
- Electrochemical Science Group, Beograd
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-MESTD-Basic Research (BR or ON)-172013)
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Stoiljković, Zora Ž. AU - Avramov-Ivić, Milka AU - Petrović, Slobodan AU - Mijin, Dušan AU - Stevanović, Sanja AU - Lačnjevac, Uroš AU - Marinković, Aleksandar PY - 2012 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1984 AB - The oxidative behaviour of amlodipine besylate was studied. The gold electrode and Au/o-MWCNT (oxidized multi-wall carbon nanotubes) were used for determination of amlodipine besylate standard and as a content of Alopres tablet, in 0.05 M NaHCO3 and in phosphate buffer (pH=11) by cyclic voltammetry and square-wave anodic stripping voltammetry. Electrode surfaces were characterized by AFM in the presence of amlodipine and the concentrations of drugs in electrolytes were simultaneously followed by HPLC. The linear dependency of the anodic currents of amlodipine besylate as standard and in Alopres tablet vs. concentration was observed in both electrolytes, but in phosphate buffer for the higher concentrations. The peak currents obtained in all experiments are more than fifty-fold higher comparing to all previously published results concerning the glassy carbon electrode and the carbon paste electrode. The gold electrode is better catalyst for anodic oxidation of amlodipine besylate than glassy carbone. The results obtained with Au/o-MWCNT show lower anodic activity comparing to previously published GC/o-MWCNT. GC/o-MWCNT is better catalyst than Au/o-MWCNT under similar experimental conditions. PB - Electrochemical Science Group, Beograd T2 - International Journal of Electrochemical Science T1 - Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode EP - 2303 IS - 3 SP - 2288 VL - 7 UR - https://hdl.handle.net/21.15107/rcub_technorep_1984 ER -
@article{ author = "Stoiljković, Zora Ž. and Avramov-Ivić, Milka and Petrović, Slobodan and Mijin, Dušan and Stevanović, Sanja and Lačnjevac, Uroš and Marinković, Aleksandar", year = "2012", abstract = "The oxidative behaviour of amlodipine besylate was studied. The gold electrode and Au/o-MWCNT (oxidized multi-wall carbon nanotubes) were used for determination of amlodipine besylate standard and as a content of Alopres tablet, in 0.05 M NaHCO3 and in phosphate buffer (pH=11) by cyclic voltammetry and square-wave anodic stripping voltammetry. Electrode surfaces were characterized by AFM in the presence of amlodipine and the concentrations of drugs in electrolytes were simultaneously followed by HPLC. The linear dependency of the anodic currents of amlodipine besylate as standard and in Alopres tablet vs. concentration was observed in both electrolytes, but in phosphate buffer for the higher concentrations. The peak currents obtained in all experiments are more than fifty-fold higher comparing to all previously published results concerning the glassy carbon electrode and the carbon paste electrode. The gold electrode is better catalyst for anodic oxidation of amlodipine besylate than glassy carbone. The results obtained with Au/o-MWCNT show lower anodic activity comparing to previously published GC/o-MWCNT. GC/o-MWCNT is better catalyst than Au/o-MWCNT under similar experimental conditions.", publisher = "Electrochemical Science Group, Beograd", journal = "International Journal of Electrochemical Science", title = "Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode", pages = "2303-2288", number = "3", volume = "7", url = "https://hdl.handle.net/21.15107/rcub_technorep_1984" }
Stoiljković, Z. Ž., Avramov-Ivić, M., Petrović, S., Mijin, D., Stevanović, S., Lačnjevac, U.,& Marinković, A.. (2012). Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode. in International Journal of Electrochemical Science Electrochemical Science Group, Beograd., 7(3), 2288-2303. https://hdl.handle.net/21.15107/rcub_technorep_1984
Stoiljković ZŽ, Avramov-Ivić M, Petrović S, Mijin D, Stevanović S, Lačnjevac U, Marinković A. Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode. in International Journal of Electrochemical Science. 2012;7(3):2288-2303. https://hdl.handle.net/21.15107/rcub_technorep_1984 .
Stoiljković, Zora Ž., Avramov-Ivić, Milka, Petrović, Slobodan, Mijin, Dušan, Stevanović, Sanja, Lačnjevac, Uroš, Marinković, Aleksandar, "Voltammetric and Square-Wave Anodic Stripping Determination of Amlodipine Besylate on Gold Electrode" in International Journal of Electrochemical Science, 7, no. 3 (2012):2288-2303, https://hdl.handle.net/21.15107/rcub_technorep_1984 .