Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres
Апстракт
Poly(epsilon-caprolactone) (PCL), a biodegradable and biocompatible aliphatic polyester has a great potential as a drug carrying material in controlled drug delivery/release systems. The most simple and economical way to tailor the release profile of active substances from biodegradable polymer matrix is by the addition of the second polymeric component in the polymer matrix, i.e. by blending. This study describes the preparation and characterization of a carbamazepine-loaded microspheres by the use of PCL blended with poly(ethylene oxide) as a drug carrying material. By the use of two-component hydrophilic/hydrophobic polymer blend as a microspheres' matrix material, release profile of the drug can be modified and dictated. The microspheres prepared by classical oil-in-water emulsion solvent evaporation technique were characterized with respect to particle size and morphology, polymer matrix composition, encapsulation efficiency, physical state of the drug and in vitro release behavio...ur. It was presented that the release profile can be modified by the presence and the amount of hydrophilic component in the starting formulation of microspheres.
Кључне речи:
poly(epsilon-caprolactone) / microspheres / carbamazepine / poly(ethylene oxide) / release behaviourИзвор:
Journal of Microencapsulation, 2013, 30, 2, 151-160Издавач:
- Informa Healthcare, London
Финансирање / пројекти:
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-MESTD-Basic Research (BR or ON)-172062)
- Развој и примена метода и материјала за мониторинг нових загађујућих и токсичних органских материја и тешких метала (RS-MESTD-Basic Research (BR or ON)-172007)
- Ministry of Education and Science of the Republic of Serbia
DOI: 10.3109/02652048.2012.704954
ISSN: 0265-2048
PubMed: 22852775
WoS: 000314148400006
Scopus: 2-s2.0-84873053908
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Pepić, Dragana AU - Nikolić, Marija AU - Grujić, Svetlana AU - Laušević, Mila AU - Đonlagić, Jasna PY - 2013 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2475 AB - Poly(epsilon-caprolactone) (PCL), a biodegradable and biocompatible aliphatic polyester has a great potential as a drug carrying material in controlled drug delivery/release systems. The most simple and economical way to tailor the release profile of active substances from biodegradable polymer matrix is by the addition of the second polymeric component in the polymer matrix, i.e. by blending. This study describes the preparation and characterization of a carbamazepine-loaded microspheres by the use of PCL blended with poly(ethylene oxide) as a drug carrying material. By the use of two-component hydrophilic/hydrophobic polymer blend as a microspheres' matrix material, release profile of the drug can be modified and dictated. The microspheres prepared by classical oil-in-water emulsion solvent evaporation technique were characterized with respect to particle size and morphology, polymer matrix composition, encapsulation efficiency, physical state of the drug and in vitro release behaviour. It was presented that the release profile can be modified by the presence and the amount of hydrophilic component in the starting formulation of microspheres. PB - Informa Healthcare, London T2 - Journal of Microencapsulation T1 - Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres EP - 160 IS - 2 SP - 151 VL - 30 DO - 10.3109/02652048.2012.704954 ER -
@article{ author = "Pepić, Dragana and Nikolić, Marija and Grujić, Svetlana and Laušević, Mila and Đonlagić, Jasna", year = "2013", abstract = "Poly(epsilon-caprolactone) (PCL), a biodegradable and biocompatible aliphatic polyester has a great potential as a drug carrying material in controlled drug delivery/release systems. The most simple and economical way to tailor the release profile of active substances from biodegradable polymer matrix is by the addition of the second polymeric component in the polymer matrix, i.e. by blending. This study describes the preparation and characterization of a carbamazepine-loaded microspheres by the use of PCL blended with poly(ethylene oxide) as a drug carrying material. By the use of two-component hydrophilic/hydrophobic polymer blend as a microspheres' matrix material, release profile of the drug can be modified and dictated. The microspheres prepared by classical oil-in-water emulsion solvent evaporation technique were characterized with respect to particle size and morphology, polymer matrix composition, encapsulation efficiency, physical state of the drug and in vitro release behaviour. It was presented that the release profile can be modified by the presence and the amount of hydrophilic component in the starting formulation of microspheres.", publisher = "Informa Healthcare, London", journal = "Journal of Microencapsulation", title = "Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres", pages = "160-151", number = "2", volume = "30", doi = "10.3109/02652048.2012.704954" }
Pepić, D., Nikolić, M., Grujić, S., Laušević, M.,& Đonlagić, J.. (2013). Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres. in Journal of Microencapsulation Informa Healthcare, London., 30(2), 151-160. https://doi.org/10.3109/02652048.2012.704954
Pepić D, Nikolić M, Grujić S, Laušević M, Đonlagić J. Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres. in Journal of Microencapsulation. 2013;30(2):151-160. doi:10.3109/02652048.2012.704954 .
Pepić, Dragana, Nikolić, Marija, Grujić, Svetlana, Laušević, Mila, Đonlagić, Jasna, "Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres" in Journal of Microencapsulation, 30, no. 2 (2013):151-160, https://doi.org/10.3109/02652048.2012.704954 . .