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Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres

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Authors
Pepić, Dragana
Nikolić, Marija
Grujić, Svetlana
Laušević, Mila
Đonlagić, Jasna
Article (Published version)
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Abstract
Poly(epsilon-caprolactone) (PCL), a biodegradable and biocompatible aliphatic polyester has a great potential as a drug carrying material in controlled drug delivery/release systems. The most simple and economical way to tailor the release profile of active substances from biodegradable polymer matrix is by the addition of the second polymeric component in the polymer matrix, i.e. by blending. This study describes the preparation and characterization of a carbamazepine-loaded microspheres by the use of PCL blended with poly(ethylene oxide) as a drug carrying material. By the use of two-component hydrophilic/hydrophobic polymer blend as a microspheres' matrix material, release profile of the drug can be modified and dictated. The microspheres prepared by classical oil-in-water emulsion solvent evaporation technique were characterized with respect to particle size and morphology, polymer matrix composition, encapsulation efficiency, physical state of the drug and in vitro release behavio...ur. It was presented that the release profile can be modified by the presence and the amount of hydrophilic component in the starting formulation of microspheres.

Keywords:
poly(epsilon-caprolactone) / microspheres / carbamazepine / poly(ethylene oxide) / release behaviour
Source:
Journal of Microencapsulation, 2013, 30, 2, 151-160
Publisher:
  • Informa Healthcare, London
Funding / projects:
  • Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-172062)
  • Development and Application of Methods and Materials for Monitoring New Organic Contaminants, Toxic Compounds and Heavy Metals (RS-172007)
  • Ministry of Education and Science of the Republic of Serbia

DOI: 10.3109/02652048.2012.704954

ISSN: 0265-2048

PubMed: 22852775

WoS: 000314148400006

Scopus: 2-s2.0-84873053908
[ Google Scholar ]
11
11
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2475
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Pepić, Dragana
AU  - Nikolić, Marija
AU  - Grujić, Svetlana
AU  - Laušević, Mila
AU  - Đonlagić, Jasna
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2475
AB  - Poly(epsilon-caprolactone) (PCL), a biodegradable and biocompatible aliphatic polyester has a great potential as a drug carrying material in controlled drug delivery/release systems. The most simple and economical way to tailor the release profile of active substances from biodegradable polymer matrix is by the addition of the second polymeric component in the polymer matrix, i.e. by blending. This study describes the preparation and characterization of a carbamazepine-loaded microspheres by the use of PCL blended with poly(ethylene oxide) as a drug carrying material. By the use of two-component hydrophilic/hydrophobic polymer blend as a microspheres' matrix material, release profile of the drug can be modified and dictated. The microspheres prepared by classical oil-in-water emulsion solvent evaporation technique were characterized with respect to particle size and morphology, polymer matrix composition, encapsulation efficiency, physical state of the drug and in vitro release behaviour. It was presented that the release profile can be modified by the presence and the amount of hydrophilic component in the starting formulation of microspheres.
PB  - Informa Healthcare, London
T2  - Journal of Microencapsulation
T1  - Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres
EP  - 160
IS  - 2
SP  - 151
VL  - 30
DO  - 10.3109/02652048.2012.704954
UR  - conv_4031
ER  - 
@article{
author = "Pepić, Dragana and Nikolić, Marija and Grujić, Svetlana and Laušević, Mila and Đonlagić, Jasna",
year = "2013",
abstract = "Poly(epsilon-caprolactone) (PCL), a biodegradable and biocompatible aliphatic polyester has a great potential as a drug carrying material in controlled drug delivery/release systems. The most simple and economical way to tailor the release profile of active substances from biodegradable polymer matrix is by the addition of the second polymeric component in the polymer matrix, i.e. by blending. This study describes the preparation and characterization of a carbamazepine-loaded microspheres by the use of PCL blended with poly(ethylene oxide) as a drug carrying material. By the use of two-component hydrophilic/hydrophobic polymer blend as a microspheres' matrix material, release profile of the drug can be modified and dictated. The microspheres prepared by classical oil-in-water emulsion solvent evaporation technique were characterized with respect to particle size and morphology, polymer matrix composition, encapsulation efficiency, physical state of the drug and in vitro release behaviour. It was presented that the release profile can be modified by the presence and the amount of hydrophilic component in the starting formulation of microspheres.",
publisher = "Informa Healthcare, London",
journal = "Journal of Microencapsulation",
title = "Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres",
pages = "160-151",
number = "2",
volume = "30",
doi = "10.3109/02652048.2012.704954",
url = "conv_4031"
}
Pepić, D., Nikolić, M., Grujić, S., Laušević, M.,& Đonlagić, J.. (2013). Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres. in Journal of Microencapsulation
Informa Healthcare, London., 30(2), 151-160.
https://doi.org/10.3109/02652048.2012.704954
conv_4031
Pepić D, Nikolić M, Grujić S, Laušević M, Đonlagić J. Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres. in Journal of Microencapsulation. 2013;30(2):151-160.
doi:10.3109/02652048.2012.704954
conv_4031 .
Pepić, Dragana, Nikolić, Marija, Grujić, Svetlana, Laušević, Mila, Đonlagić, Jasna, "Release behaviour of carbamazepine-loaded poly(epsilon-caprolactone)/poly(ethylene oxide) microspheres" in Journal of Microencapsulation, 30, no. 2 (2013):151-160,
https://doi.org/10.3109/02652048.2012.704954 .,
conv_4031 .

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