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dc.creatorRajilić-Stojanović, Mirjana
dc.creatorHeilig, Hans G. H. J.
dc.creatorTims, Sebastian
dc.creatorZoetendal, Erwin G.
dc.creatorde Vos, Willem M.
dc.date.accessioned2021-03-10T12:15:08Z
dc.date.available2021-03-10T12:15:08Z
dc.date.issued2013
dc.identifier.issn1462-2912
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2518
dc.description.abstractThe microbiota that colonizes the human intestinal tract is complex and its structure is specific for each of us. In this study we expand the knowledge about the stability of the subject-specific microbiota and show that this ecosystem is stable in short-term intervals ( lt 1 year) but also during long periods of time ( gt 10 years). The faecal microbiota composition of five unrelated and healthy subjects was analysed using a comprehensive and highly reproducible phylogenetic microarray, the HITChip. The results show that the use of antibiotics, application of specific dietary regimes and distant travelling have limited impact on the microbiota composition. Several anaerobic genera, including Bifidobacterium and a number of genera within the Bacteroidetes and the Firmicutes phylum, exhibit significantly higher similarity than the total microbiota. Although the gut microbiota contains subject-specific species, the presence of which is preserved throughout the years, their relative abundance changes considerably. Consequently, the recently proposed enterotype status appears to be a varying characteristic of the microbiota. Our data show that the intestinal microbiota contains a core community of permanent colonizers, and that environmentally introduced changes of the microbiota throughout adulthood are primarily affecting the abundance but not the presence of specific microbial species.en
dc.publisherWiley, Hoboken
dc.rightsrestrictedAccess
dc.sourceEnvironmental Microbiology
dc.titleLong-term monitoring of the human intestinal microbiota compositionen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1159
dc.citation.issue4
dc.citation.other15(4): 1146-1159
dc.citation.rankM21
dc.citation.spage1146
dc.citation.volume15
dc.identifier.doi10.1111/1462-2920.12023
dc.identifier.rcubconv_4097
dc.identifier.scopus2-s2.0-84875904427
dc.identifier.wos000317287200013
dc.type.versionpublishedVersion


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