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dc.creatorKrezović, Bojana D.
dc.creatorDimitrijević, Suzana
dc.creatorFilipović, Jovanka M.
dc.creatorNikolić, Rajko R.
dc.creatorTomić, Simonida
dc.date.accessioned2021-03-10T12:16:45Z
dc.date.available2021-03-10T12:16:45Z
dc.date.issued2013
dc.identifier.issn0170-0839
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2543
dc.description.abstractNew semi-interpenetrating networks (semi-IPNHs) (P(HEMA/IA)/PVP) were prepared by free radical crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA, 5 mol%), in the presence of poly(vinyl pyrrolidone) (PVP, 2, 5, and 10 mol%), as an interpenetrating agent. The structure of the semi-IPNHs was confirmed by Fourier transform infrared spectroscopy, and morphology study was performed by scanning electron microscopy, which revealed the characteristic porous morphology. The results obtained by dynamic mechanical analysis showed the improvement of mechanical properties with increasing PVP content in semi-IPNs. The maximum swelling was observed for all studied systems at a slightly acidic media (around pH 6), so it can be said that the content of PVP has no influence on the swelling behavior, in the PVP range investigated. Along with the pH sensitivity, which was expected due to the presence of IA, semi-IPNHs showed temperature-sensitive swelling properties, with the lower critical solution temperature value around 41 degrees C, which is in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus, and C. albicans pathogens. It was noticed that the antimicrobial potential depends on type of microbes, time of exposure, and PVP content in the samples. Due to their good antimicrobial and mechanical properties these stimuli-sensitive semi-IPNHs have potential to be used as biomaterials for the applications in medicine and pharmacy.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.rightsrestrictedAccess
dc.sourcePolymer Bulletin
dc.subjectSemi-interpenetrating hydrogel networksen
dc.subject2-Hydroxyethyl methacrylateen
dc.subjectItaconic aciden
dc.subjectPoly(N-vinylpyrrolidone)en
dc.subjectMorphologyen
dc.subjectMechanical propertiesen
dc.subjectSwellingen
dc.subjectAntimicrobial activityen
dc.titleAntimicrobial P(HEMA/IA)/PVP semi-interpenetrating network hydrogelsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage819
dc.citation.issue3
dc.citation.other70(3): 809-819
dc.citation.rankM22
dc.citation.spage809
dc.citation.volume70
dc.identifier.doi10.1007/s00289-012-0830-y
dc.identifier.rcubconv_4082
dc.identifier.scopus2-s2.0-84878572286
dc.identifier.wos000316226300005
dc.type.versionpublishedVersion


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