Приказ основних података о документу

dc.creatorVastag, Gyongyi
dc.creatorApostolov, Suzana
dc.creatorMatijević, Borko M.
dc.creatorMarinković, Aleksandar
dc.date.accessioned2021-03-10T12:27:39Z
dc.date.available2021-03-10T12:27:39Z
dc.date.issued2014
dc.identifier.issn0103-5053
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2717
dc.description.abstractThe potential biological activity of a molecule largely depends on its lipophilicity. The lipophilicity of derivatives of N-substituted-2-phenylacetamide was investigated experimentally, by applying thin-layer chromatography on reversed phase (RP-TLC on RP 18 F-254s) in the presence of ethanol and dioxane and by using relevant software packages. In order to establish dependence between lipophilicity obtained in different ways, linear regression analysis and multivariate methods were used. Approximately similar groupings of lipophilic parameters and tested compounds were registered in case of both chemometric methods. The obtained results confirm the fact that the applied linear regression analysis and multivariate analysis provide opportunities for comparing chromatographic retention data and lipophilic parameters of the investigated phenylacetamide derivatives. Results suggest that the lipophilicity of investigated molecules largely depends on the nature of the substituents linked to nitrogen atom and on the other hand that the chromatographic retention constants, R-M(0), determined by RP-TLC method, are similar to the standard measure of lipophilicity, log P, which makes this method appropriate for predicting lipophilicity.en
dc.publisherSoc Brasileira Quimica, Sao Paulo
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceJournal of the Brazilian Chemical Society
dc.subjectN-substituted-2-phenylacetamidesen
dc.subjectlipophilicityen
dc.subjectRP-TLCen
dc.subjectchemometricsen
dc.titleChemometric Approach in Studying of the Retention Behavior and Lipophilicity of Potentially Biologically Active N-Substituted-2-phenylacetamide Derivativesen
dc.typearticle
dc.rights.licenseBY
dc.citation.epage1955
dc.citation.issue11
dc.citation.other25(11): 1948-1955
dc.citation.rankM23
dc.citation.spage1948
dc.citation.volume25
dc.identifier.doi10.5935/0103-5053.20140174
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/834/2714.pdf
dc.identifier.scopus2-s2.0-84908680756
dc.identifier.wos000345241700004
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу