In Vitro Silver Ion Release Kinetics from Nanosilver/Poly(vinyl alcohol) Hydrogels Synthesized by Gamma Irradiation
Само за регистроване кориснике
2014
Аутори
Krstić, Jelena I.Spasojević, Jelena P.
Radosavljević, Aleksandra
Perić-Grujić, Aleksandra
Durić, Momčilo
Kačarević-Popović, Zorica M.
Popović, Srđan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A nanosilver (nano-Ag)/poly(vinyl alcohol) (PVA) hydrogel device was synthesized with irradiation because it is a highly suitable tool for enhanced nano-Ag technologies and biocompatible controlled release formulations. The amount of the Ag+ ions released in vitro by the nano-Ag/PVA hydrogel device was in the antimicrobial parts per million concentration range. The modeling of the Ag+ ion release kinetics with the elements of the drug-delivery paradigm revealed the best fit solution (R-2 gt 0.99) for the Kopcha and Makoid-Banakar's pharmacokinetic dissolution models. The term A/B, derived from the Kopcha model, indicated that the nano-Ag/PVA hydrogel was mainly an Ag+-ion diffusion-controlled device. Makoid-Banakar's parameter and the short time approximated Ag+-ion diffusion constant reflected the importance of the size of the Ag nanoparticles. However, it appeared that the cell oxidation potential of the Ag nanoparticles depended on the diffusion characteristics of the fluid penetrat...ing into the Ag/PVA nanosystem.
Кључне речи:
composites / drug-delivery systems / hydrophilic polymers / gels / irradiationИзвор:
Journal of Applied Polymer Science, 2014, 131, 11Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Функционални, функционализовани и усавршени нано материјали (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
- International Atomic Energy AgencyInternational Atomic Energy Agency [CRP:F22051, 16733]
DOI: 10.1002/app.40321
ISSN: 0021-8995
WoS: 000332387300020
Scopus: 2-s2.0-84897655580
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Krstić, Jelena I. AU - Spasojević, Jelena P. AU - Radosavljević, Aleksandra AU - Perić-Grujić, Aleksandra AU - Durić, Momčilo AU - Kačarević-Popović, Zorica M. AU - Popović, Srđan PY - 2014 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2773 AB - A nanosilver (nano-Ag)/poly(vinyl alcohol) (PVA) hydrogel device was synthesized with irradiation because it is a highly suitable tool for enhanced nano-Ag technologies and biocompatible controlled release formulations. The amount of the Ag+ ions released in vitro by the nano-Ag/PVA hydrogel device was in the antimicrobial parts per million concentration range. The modeling of the Ag+ ion release kinetics with the elements of the drug-delivery paradigm revealed the best fit solution (R-2 gt 0.99) for the Kopcha and Makoid-Banakar's pharmacokinetic dissolution models. The term A/B, derived from the Kopcha model, indicated that the nano-Ag/PVA hydrogel was mainly an Ag+-ion diffusion-controlled device. Makoid-Banakar's parameter and the short time approximated Ag+-ion diffusion constant reflected the importance of the size of the Ag nanoparticles. However, it appeared that the cell oxidation potential of the Ag nanoparticles depended on the diffusion characteristics of the fluid penetrating into the Ag/PVA nanosystem. PB - Wiley, Hoboken T2 - Journal of Applied Polymer Science T1 - In Vitro Silver Ion Release Kinetics from Nanosilver/Poly(vinyl alcohol) Hydrogels Synthesized by Gamma Irradiation IS - 11 VL - 131 DO - 10.1002/app.40321 ER -
@article{ author = "Krstić, Jelena I. and Spasojević, Jelena P. and Radosavljević, Aleksandra and Perić-Grujić, Aleksandra and Durić, Momčilo and Kačarević-Popović, Zorica M. and Popović, Srđan", year = "2014", abstract = "A nanosilver (nano-Ag)/poly(vinyl alcohol) (PVA) hydrogel device was synthesized with irradiation because it is a highly suitable tool for enhanced nano-Ag technologies and biocompatible controlled release formulations. The amount of the Ag+ ions released in vitro by the nano-Ag/PVA hydrogel device was in the antimicrobial parts per million concentration range. The modeling of the Ag+ ion release kinetics with the elements of the drug-delivery paradigm revealed the best fit solution (R-2 gt 0.99) for the Kopcha and Makoid-Banakar's pharmacokinetic dissolution models. The term A/B, derived from the Kopcha model, indicated that the nano-Ag/PVA hydrogel was mainly an Ag+-ion diffusion-controlled device. Makoid-Banakar's parameter and the short time approximated Ag+-ion diffusion constant reflected the importance of the size of the Ag nanoparticles. However, it appeared that the cell oxidation potential of the Ag nanoparticles depended on the diffusion characteristics of the fluid penetrating into the Ag/PVA nanosystem.", publisher = "Wiley, Hoboken", journal = "Journal of Applied Polymer Science", title = "In Vitro Silver Ion Release Kinetics from Nanosilver/Poly(vinyl alcohol) Hydrogels Synthesized by Gamma Irradiation", number = "11", volume = "131", doi = "10.1002/app.40321" }
Krstić, J. I., Spasojević, J. P., Radosavljević, A., Perić-Grujić, A., Durić, M., Kačarević-Popović, Z. M.,& Popović, S.. (2014). In Vitro Silver Ion Release Kinetics from Nanosilver/Poly(vinyl alcohol) Hydrogels Synthesized by Gamma Irradiation. in Journal of Applied Polymer Science Wiley, Hoboken., 131(11). https://doi.org/10.1002/app.40321
Krstić JI, Spasojević JP, Radosavljević A, Perić-Grujić A, Durić M, Kačarević-Popović ZM, Popović S. In Vitro Silver Ion Release Kinetics from Nanosilver/Poly(vinyl alcohol) Hydrogels Synthesized by Gamma Irradiation. in Journal of Applied Polymer Science. 2014;131(11). doi:10.1002/app.40321 .
Krstić, Jelena I., Spasojević, Jelena P., Radosavljević, Aleksandra, Perić-Grujić, Aleksandra, Durić, Momčilo, Kačarević-Popović, Zorica M., Popović, Srđan, "In Vitro Silver Ion Release Kinetics from Nanosilver/Poly(vinyl alcohol) Hydrogels Synthesized by Gamma Irradiation" in Journal of Applied Polymer Science, 131, no. 11 (2014), https://doi.org/10.1002/app.40321 . .