Приказ основних података о документу

dc.creatorWacklin, Pirjo
dc.creatorTuimala, Jarno
dc.creatorNikkila, Janne
dc.creatorTims, Sebastian
dc.creatorMakivuokko, Harri
dc.creatorAlakulppi, Noora
dc.creatorLaine, Pia
dc.creatorRajilić-Stojanović, Mirjana
dc.creatorPaulin, Lars
dc.creatorde Vos, Willem M.
dc.creatorMatto, Jaana
dc.date.accessioned2021-03-10T12:33:47Z
dc.date.available2021-03-10T12:33:47Z
dc.date.issued2014
dc.identifier.issn1932-6203
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2814
dc.description.abstractThe human intestine is colonised with highly diverse and individually defined microbiota, which likely has an impact on the host well-being. Drivers of the individual variation in the microbiota compositions are multifactorial and include environmental, host and dietary factors. We studied the impact of the host secretor status, encoded by fucosyltransferase 2 (FUT2) -gene, on the intestinal microbiota composition. Secretor status determines the expression of the ABH and Lewis histo-blood group antigens in the intestinal mucosa. The study population was comprised of 14 non-secretor (FUT2 rs601338 genotype AA) and 57 secretor (genotypes GG and AG) adult individuals of western European descent. Intestinal microbiota was analyzed by PCR-DGGE and for a subset of 12 non-secretor subjects and 12 secretor subjects additionally by the 16S rRNA gene pyrosequencing and the HITChip phylogenetic microarray analysis. All three methods showed distinct clustering of the intestinal microbiota and significant differences in abundances of several taxa representing dominant microbiota between the non-secretors and the secretors as well as between the FUT2 genotypes. In addition, the non-secretors had lower species richness than the secretors. The soft clustering of microbiota into enterotypes (ET) 1 and 3 showed that the non-secretors had a higher probability of belonging to ET1 and the secretors to ET3. Our study shows that secretor status and FUT2 polymorphism are associated with the composition of human intestinal microbiota, and appears thus to be one of the key drivers affecting the individual variation of human intestinal microbiota.en
dc.publisherPublic Library Science, San Francisco
dc.relationNetherlands Organization for Scientific Research (Spinoza Grant)
dc.relationFinnish Academy of SciencesAcademy of Finland [141140]
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePLoS One
dc.titleFaecal Microbiota Composition in Adults Is Associated with the FUT2 Gene Determining the Secretor Statusen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue4
dc.citation.other9(4): -
dc.citation.rankM21
dc.citation.volume9
dc.identifier.doi10.1371/journal.pone.0094863
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/9166/file.pdf
dc.identifier.pmid24733310
dc.identifier.scopus2-s2.0-84899648332
dc.identifier.wos000336970400123
dc.type.versionpublishedVersion


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Приказ основних података о документу