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dc.creatorMarić, Ljiljana B.
dc.creatorJović, Branislav D.
dc.creatorPetrović, Slobodan
dc.creatorNikolić, Aleksandar M.
dc.creatorHomsek, Irena J.
dc.date.accessioned2021-03-10T12:35:25Z
dc.date.available2021-03-10T12:35:25Z
dc.date.issued2014
dc.identifier.issn0352-5139
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/2840
dc.description.abstractThis paper reports the use of near infrared (NIR) spectroscopy as a process analytical technology (PAT) tool for monitoring the metformin (N,N-dimethylimidodicarbonimidic diamide) hydrochloride and poly(vinyl pyrrolidone) (PVP) mixing process, which is the first stage in tablet production. Blend homogeneity was tested using the non-invasive NIR spectroscopy method and the partial least squares (PLS) regression model was applied for the analysis of the obtained spectra. Simultaneously, the critical parameter (metformin hydrochloride content) was monitored by a classical analytical technique, the validated HPLC method, commonly used for this purpose. Based on the high sensitivity of the model developed in this study, as well as the established correlation among the results obtained by different methods, it could be concluded that the proposed rapid and non-invasive technique. could be an effecttive tool for the monitoring of one of the critical manufacturing steps in the production solid dosage forms.en
dc.publisherSrpsko hemijsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectPATen
dc.subjectNIR spectroscopyen
dc.subjectPLSen
dc.subjectmetformin hydrochlorideen
dc.subjectblend uniformity analysisen
dc.titleThe application of NIR spectroscopy with chemometric analysis for monitoring a powder blending processen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage340
dc.citation.issue3
dc.citation.other79(3): 331-340
dc.citation.rankM23
dc.citation.spage331
dc.citation.volume79
dc.identifier.doi10.2298/JSC010413080M
dc.identifier.rcubconv_4387
dc.identifier.scopus2-s2.0-84896936527
dc.identifier.wos000333770600007
dc.type.versionpublishedVersion


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