Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?
2015
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Аутори
Rajilić-Stojanović, MirjanaJonkers, Daisy M.
Salonen, Anne
Hanevik, Kurt
Raes, Jeroen
Jalanka, Jonna
de Vos, Willem M.
Manichanh, Chaysavanh
Golić, Nataša
Enck, Paul
Philippou, Elena
Iraqi, Fuad A.
Clarke, Gerard
Spiller, Robin C.
Penders, John
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specifi c foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review p...rovides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter) related in the pathophysiology of IBS.
Извор:
American Journal of Gastroenterology, 2015, 110, 2, 278-287Издавач:
- Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
- international network GENIEUR (Genes in Irritable Bowel Syndrome Europe) - COST program [BM1106]
- National Institute for Health ResearchNational Institute for Health Research (NIHR) [NF-SI-0509-10005] Funding Source: researchfish
DOI: 10.1038/ajg.2014.427
ISSN: 0002-9270
PubMed: 25623659
WoS: 000351915900006
Scopus: 2-s2.0-84991325356
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Rajilić-Stojanović, Mirjana AU - Jonkers, Daisy M. AU - Salonen, Anne AU - Hanevik, Kurt AU - Raes, Jeroen AU - Jalanka, Jonna AU - de Vos, Willem M. AU - Manichanh, Chaysavanh AU - Golić, Nataša AU - Enck, Paul AU - Philippou, Elena AU - Iraqi, Fuad A. AU - Clarke, Gerard AU - Spiller, Robin C. AU - Penders, John PY - 2015 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2973 AB - Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specifi c foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review provides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter) related in the pathophysiology of IBS. PB - Lippincott Williams & Wilkins, Philadelphia T2 - American Journal of Gastroenterology T1 - Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena? EP - 287 IS - 2 SP - 278 VL - 110 DO - 10.1038/ajg.2014.427 ER -
@article{ author = "Rajilić-Stojanović, Mirjana and Jonkers, Daisy M. and Salonen, Anne and Hanevik, Kurt and Raes, Jeroen and Jalanka, Jonna and de Vos, Willem M. and Manichanh, Chaysavanh and Golić, Nataša and Enck, Paul and Philippou, Elena and Iraqi, Fuad A. and Clarke, Gerard and Spiller, Robin C. and Penders, John", year = "2015", abstract = "Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specifi c foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review provides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter) related in the pathophysiology of IBS.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "American Journal of Gastroenterology", title = "Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?", pages = "287-278", number = "2", volume = "110", doi = "10.1038/ajg.2014.427" }
Rajilić-Stojanović, M., Jonkers, D. M., Salonen, A., Hanevik, K., Raes, J., Jalanka, J., de Vos, W. M., Manichanh, C., Golić, N., Enck, P., Philippou, E., Iraqi, F. A., Clarke, G., Spiller, R. C.,& Penders, J.. (2015). Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?. in American Journal of Gastroenterology Lippincott Williams & Wilkins, Philadelphia., 110(2), 278-287. https://doi.org/10.1038/ajg.2014.427
Rajilić-Stojanović M, Jonkers DM, Salonen A, Hanevik K, Raes J, Jalanka J, de Vos WM, Manichanh C, Golić N, Enck P, Philippou E, Iraqi FA, Clarke G, Spiller RC, Penders J. Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?. in American Journal of Gastroenterology. 2015;110(2):278-287. doi:10.1038/ajg.2014.427 .
Rajilić-Stojanović, Mirjana, Jonkers, Daisy M., Salonen, Anne, Hanevik, Kurt, Raes, Jeroen, Jalanka, Jonna, de Vos, Willem M., Manichanh, Chaysavanh, Golić, Nataša, Enck, Paul, Philippou, Elena, Iraqi, Fuad A., Clarke, Gerard, Spiller, Robin C., Penders, John, "Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?" in American Journal of Gastroenterology, 110, no. 2 (2015):278-287, https://doi.org/10.1038/ajg.2014.427 . .