Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility
Само за регистроване кориснике
2015
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Oxidized cellulose has a long history of safe and effective use in medical applications. In this paper, research has been directed towards obtaining hormone-active cellulose fibers in the form of an artificial insulin depot, and examination of its biocompatibility regarding cytotoxicity, sensitization, and irritation. The procedure of obtaining the fibrous insulin depot is based on the modification of cotton fibers with sodium periodate, followed by chemisorption of insulin from insulin aqueous solutions. In order to optimize the insulin chemisorption process, the influence of the fiber structure parameters, i.e. the aldehyde group content and iodine sorption value (ISV) on the chemisorption capacity was examined. The obtained artificial depot, containing approximate to 55 mg insulin/g of fibers, has been characterized in vitro by investigation of the desorption kinetics of the insulin from the fibrous depot. It has been shown that insulin is controllably released in quantities of 1.3-...1.6 mg of insulin during 24 hours, in the course of 20 days. The results of biocompatibility tests have shown that the examined artificial depot neither shows irritating effects nor provokes sensitizing or cytotoxic effects. Therefore, these materials are acceptable for use in a direct contact with tissue of a living organism.
Кључне речи:
Oxidized cotton fibers / Artificial insulin depot / Chemisorption / Desorption / BiocompatibilityИзвор:
Fibers and Polymers, 2015, 16, 5, 997-1004Издавач:
- Korean Fiber Soc, Seoul
Финансирање / пројекти:
- Функционализација, карактеризација и примена целулозе и деривата целулозе (RS-MESTD-Basic Research (BR or ON)-172029)
DOI: 10.1007/s12221-015-0997-6
ISSN: 1229-9197
WoS: 000355360300006
Scopus: 2-s2.0-84930627726
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Pejić, Biljana AU - Medović-Baralić, Adela AU - Kojić, Zvezdana AU - Škundrić, Petar AU - Kostić, Mirjana PY - 2015 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2983 AB - Oxidized cellulose has a long history of safe and effective use in medical applications. In this paper, research has been directed towards obtaining hormone-active cellulose fibers in the form of an artificial insulin depot, and examination of its biocompatibility regarding cytotoxicity, sensitization, and irritation. The procedure of obtaining the fibrous insulin depot is based on the modification of cotton fibers with sodium periodate, followed by chemisorption of insulin from insulin aqueous solutions. In order to optimize the insulin chemisorption process, the influence of the fiber structure parameters, i.e. the aldehyde group content and iodine sorption value (ISV) on the chemisorption capacity was examined. The obtained artificial depot, containing approximate to 55 mg insulin/g of fibers, has been characterized in vitro by investigation of the desorption kinetics of the insulin from the fibrous depot. It has been shown that insulin is controllably released in quantities of 1.3-1.6 mg of insulin during 24 hours, in the course of 20 days. The results of biocompatibility tests have shown that the examined artificial depot neither shows irritating effects nor provokes sensitizing or cytotoxic effects. Therefore, these materials are acceptable for use in a direct contact with tissue of a living organism. PB - Korean Fiber Soc, Seoul T2 - Fibers and Polymers T1 - Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility EP - 1004 IS - 5 SP - 997 VL - 16 DO - 10.1007/s12221-015-0997-6 ER -
@article{ author = "Pejić, Biljana and Medović-Baralić, Adela and Kojić, Zvezdana and Škundrić, Petar and Kostić, Mirjana", year = "2015", abstract = "Oxidized cellulose has a long history of safe and effective use in medical applications. In this paper, research has been directed towards obtaining hormone-active cellulose fibers in the form of an artificial insulin depot, and examination of its biocompatibility regarding cytotoxicity, sensitization, and irritation. The procedure of obtaining the fibrous insulin depot is based on the modification of cotton fibers with sodium periodate, followed by chemisorption of insulin from insulin aqueous solutions. In order to optimize the insulin chemisorption process, the influence of the fiber structure parameters, i.e. the aldehyde group content and iodine sorption value (ISV) on the chemisorption capacity was examined. The obtained artificial depot, containing approximate to 55 mg insulin/g of fibers, has been characterized in vitro by investigation of the desorption kinetics of the insulin from the fibrous depot. It has been shown that insulin is controllably released in quantities of 1.3-1.6 mg of insulin during 24 hours, in the course of 20 days. The results of biocompatibility tests have shown that the examined artificial depot neither shows irritating effects nor provokes sensitizing or cytotoxic effects. Therefore, these materials are acceptable for use in a direct contact with tissue of a living organism.", publisher = "Korean Fiber Soc, Seoul", journal = "Fibers and Polymers", title = "Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility", pages = "1004-997", number = "5", volume = "16", doi = "10.1007/s12221-015-0997-6" }
Pejić, B., Medović-Baralić, A., Kojić, Z., Škundrić, P.,& Kostić, M.. (2015). Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility. in Fibers and Polymers Korean Fiber Soc, Seoul., 16(5), 997-1004. https://doi.org/10.1007/s12221-015-0997-6
Pejić B, Medović-Baralić A, Kojić Z, Škundrić P, Kostić M. Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility. in Fibers and Polymers. 2015;16(5):997-1004. doi:10.1007/s12221-015-0997-6 .
Pejić, Biljana, Medović-Baralić, Adela, Kojić, Zvezdana, Škundrić, Petar, Kostić, Mirjana, "Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility" in Fibers and Polymers, 16, no. 5 (2015):997-1004, https://doi.org/10.1007/s12221-015-0997-6 . .