Приказ основних података о документу

dc.creatorDimić, Ivana
dc.creatorCvijović-Alagić, Ivana
dc.creatorObradović, Nataša
dc.creatorPetrović, Jelena
dc.creatorPutić, Slaviša
dc.creatorRakin, Marko
dc.creatorBugarski, Branko
dc.date.accessioned2021-03-10T12:51:28Z
dc.date.available2021-03-10T12:51:28Z
dc.date.issued2015
dc.identifier.issn0352-5139
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3087
dc.description.abstractMetallic materials, such as Co-Cr-Mo alloys, are exposed to aggressive conditions in the oral cavity that represents an ideal environment for metallic ion release and biodegradation. The metallic ions released from dental materials can cause local and/or systemic adverse effects in the human body. Therefore, dental materials are required to possess appropriate mechanical, physical, chemical and biological properties. The biocompatibility of metallic materials is very important for dental applications. Accordingly, the aim of this study was to examine metallic ion release and cytotoxicity of Co-30Cr-5Mo cast alloy as the initial phase of biocompatibility evaluation. Determination of the viability of human (MRC-5) and animal (L929) fibroblast cells were conducted using three in vitro test methods: the colorimetric methyl-thiazol-tetrazolium (MTT) test, the dye exclusion test (DET) and the agar diffusion test (ADT). Furthermore, the morphology and growth of the cells were analyzed using scanning electron microscopy (SEM). The obtained results indicated that Co-30Cr-5Mo alloy did not release harmful elements in concentrations high enough to have detrimental effects on human and animal fibroblasts under the given experimental conditions. Moreover, the fibroblast cells showed good adhesion on the surface of the Co-30Cr-5Mo alloy. Therefore, it could be concluded that Co-30Cr-5Mo alloy is a biocompatible material that could be safely used in dentistry.en
dc.publisherSrpsko hemijsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/174004/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectCo-based alloyen
dc.subjectbiomaterialsen
dc.subjectcytotoxicityen
dc.subjectfibroblastsen
dc.titleIn vitro biocompatibility assessment of Co-Cr-Mo dental cast alloyen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage1552
dc.citation.issue12
dc.citation.other80(12): 1541-1552
dc.citation.rankM23
dc.citation.spage1541
dc.citation.volume80
dc.identifier.doi10.2298/JSC150505070M
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/1094/3084.pdf
dc.identifier.scopus2-s2.0-84983402048
dc.identifier.wos000367186500008
dc.type.versionpublishedVersion


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Приказ основних података о документу