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dc.creatorPajić-Lijaković, Ivana
dc.creatorLević, Steva
dc.creatorNedović, Viktor
dc.creatorBugarski, Branko
dc.date.accessioned2021-03-10T12:53:38Z
dc.date.available2021-03-10T12:53:38Z
dc.date.issued2015
dc.identifier.issn0927-7765
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3120
dc.description.abstractIrreversible nature of matrix structural changes around the immobilized cell aggregates caused by cell expansion is considered within the Ca-alginate microbeads. It is related to various effects: (1) cell-bulk surface effects (cell-polymer mechanical interactions) and cell surface-polymer surface effects (cell-polymer electrostatic interactions) at the bio-interface, (2) polymer-bulk volume effects (polymer-polymer mechanical and electrostatic interactions) within the perturbed boundary layers around the cell aggregates, (3) cumulative surface and volume effects within the parts of the microbead, and (4) macroscopic effects within the microbead as a whole based on multi scale modeling approaches. All modeling levels are discussed at two time scales i.e. long time scale (cell growth time) and short time scale (cell rearrangement time). Matrix structural changes results in the resistance stress generation which have the feedback impact on: (1) single and collective cell migrations, (2) cell deformation and orientation, (3) decrease of cell-to-cell separation distances, and (4) cell growth. Herein, an attempt is made to discuss and connect various multi scale modeling approaches on a range of time and space scales which have been proposed in the literature in order to shed further light to this complex course-consequence phenomenon which induces the anomalous nature of energy dissipation during the structural changes of cell aggregates and matrix quantified by the damping coefficients (the orders of the fractional derivatives). Deeper insight into the matrix partial disintegration within the boundary layers is useful for understanding and minimizing the polymer matrix resistance stress generation within the interface and on that base optimizing cell growth.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.rightsrestrictedAccess
dc.sourceColloids and Surfaces B-Biointerfaces
dc.subjectCa-alginate microbeadsen
dc.subjectHydrogel partial disintegrationen
dc.subjectAnomalous nature of energy dissipationen
dc.subjectResistance matrix stressen
dc.subjectMathematical modelingen
dc.titleBiointerface dynamics - Multi scale modeling considerationsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage245
dc.citation.other132: 236-245
dc.citation.rankM21
dc.citation.spage236
dc.citation.volume132
dc.identifier.doi10.1016/j.colsurfb.2015.05.013
dc.identifier.pmid26047886
dc.identifier.rcubconv_4753
dc.identifier.scopus2-s2.0-84936774887
dc.identifier.wos000358094000029
dc.type.versionpublishedVersion


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