Antibacterial activity of copper-containing clinoptilolite/PVC composites toward clinical isolate of Acinetobacter baumannii

Abstract

The multidrug-resistant bacteria Acinetobacter baumannii cause serious hospital infections. Commercial poly(vinyl chloride) (PVC) used for endotracheal tubes was modified in order to obtain a composite with an antibacterial effect towards a clinical isolate of A. baumannii ST145. The composites were prepared by addition of different amounts of copper-containing zeolite tuff (CuZ) and by successive impregnation with D-tyrosine (D-Tyr) solution. The composites that were obtained by addition of CuZ (CuZ PVC) only did not exhibit an antibacterial effect. The impregnation of the CuZ PVC by D-Tyr resulted in an antibacterial effect which was explained by a synergistic effect of CuZ and D-Tyr. Rheological tests confirmed that the modification of PVC by CuZ does not affect its processability and reformability.