Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery
2015
Аутори
Knežević, Nikola Ž.Milenković, Sanja
Jović, Danica
Lazarević, Slavica
Mrđanović, Jasminka
Đorđević, Aleksandar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.
Извор:
Advances in Materials Science and Engineering, 2015, 2015Издавач:
- Hindawi Ltd, London
Финансирање / пројекти:
- Функционални, функционализовани и усавршени нано материјали (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
- Синтеза, развој технологија добијања и примена наноструктурних мултифункционалних материјала дефинисаних својстава (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
DOI: 10.1155/2015/567350
ISSN: 1687-8434
WoS: 000358954100001
Scopus: 2-s2.0-84938614379
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Knežević, Nikola Ž. AU - Milenković, Sanja AU - Jović, Danica AU - Lazarević, Slavica AU - Mrđanović, Jasminka AU - Đorđević, Aleksandar PY - 2015 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3130 AB - Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues. PB - Hindawi Ltd, London T2 - Advances in Materials Science and Engineering T1 - Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery VL - 2015 DO - 10.1155/2015/567350 ER -
@article{ author = "Knežević, Nikola Ž. and Milenković, Sanja and Jović, Danica and Lazarević, Slavica and Mrđanović, Jasminka and Đorđević, Aleksandar", year = "2015", abstract = "Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.", publisher = "Hindawi Ltd, London", journal = "Advances in Materials Science and Engineering", title = "Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery", volume = "2015", doi = "10.1155/2015/567350" }
Knežević, N. Ž., Milenković, S., Jović, D., Lazarević, S., Mrđanović, J.,& Đorđević, A.. (2015). Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. in Advances in Materials Science and Engineering Hindawi Ltd, London., 2015. https://doi.org/10.1155/2015/567350
Knežević NŽ, Milenković S, Jović D, Lazarević S, Mrđanović J, Đorđević A. Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. in Advances in Materials Science and Engineering. 2015;2015. doi:10.1155/2015/567350 .
Knežević, Nikola Ž., Milenković, Sanja, Jović, Danica, Lazarević, Slavica, Mrđanović, Jasminka, Đorđević, Aleksandar, "Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery" in Advances in Materials Science and Engineering, 2015 (2015), https://doi.org/10.1155/2015/567350 . .