Show simple item record

dc.creatorHoppe, Alexander
dc.creatorBrandl, Andreas
dc.creatorBleiziffer, Oliver
dc.creatorArkudas, Andreas
dc.creatorHorch, Raymund E.
dc.creatorJokić, Bojan
dc.creatorJanaćković, Đorđe
dc.creatorBoccaccini, Aldo R.
dc.date.accessioned2021-03-10T12:55:01Z
dc.date.available2021-03-10T12:55:01Z
dc.date.issued2015
dc.identifier.issn0928-4931
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3142
dc.description.abstractCobalt ions are known to stimulate angiogenesis via inducing hypoxic conditions and hence are interesting agents to be used in conjunction with bioactive glasses (BGs) in bone tissue engineering approaches. In this work we investigated in vitro cell biocompatibility of Co releasing 1393 BG composition (in wt.%: 53SiO(2), 6Na(2)O, 12K(2)O, 5MgO, 20CaO, and 4P(2)O(5)) derived scaffolds with osteoblast-like cells (MG-63) and human dermal microvascular endothelial cells (hDMECs). Cell viability, cell number and cell morphology of osteoblast-like cells in contact with particulate glass and 3D scaffolds were assessed showing good biocompatibility of 1393 reference material and with 1 wt.% CoO addition whereby 5 wt.% of CoO in the glass showed cytotoxicity. Furthermore for 1393 with 1 wt.% of CoO increased mitochondrial activity was measured. Similar observations were made with hDMECs: while 1393 and 1393 with 1 wt.% CoO were biocompatible and the endothelial phenotype was retained, 5 wt.% CoO containing BG showed cytotoxic effects after 1 week of cell culture. In conclusion, 1 wt.% Co containing BG was biocompatible with osteoblast like cells and endothelial cells and showed slightly stimulating effects on osteoblast-like cells whereas the addition of 5 wt.% CoO seems to exceed the vital therapeutic ranges of Co ions being released in physiological fluids.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationEmerging Fields Initiative (EFI) of the University of Erlangen-Nurnberg [Tech_06 TOPbiomat]
dc.rightsrestrictedAccess
dc.sourceMaterials Science & Engineering C-Materials for Biological Applications
dc.subjectCobalten
dc.subjectBioactive glassen
dc.subjectAngiogenesisen
dc.subjectEndothelial cellsen
dc.titleIn vitro cell response to Co-containing 1393 bioactive glassen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage163
dc.citation.other57: 157-163
dc.citation.rankM22
dc.citation.spage157
dc.citation.volume57
dc.identifier.doi10.1016/j.msec.2015.07.014
dc.identifier.pmid26354250
dc.identifier.rcubconv_4796
dc.identifier.scopus2-s2.0-84938389346
dc.identifier.wos000361779400018
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record