Conformation of N-substituted 2-phenylbutanamides

Abstract

Various N-substituted 2-phenylbutanamides, CH3CH2CH(Ph)CONHR, where R is ethyl, n-butyl, i-butyl, cyclohexyl and phenyl, were synthesized. They were characterized by m.p., FT-IR, 1H NMR and mass spectra. Depending on the kind of substituent on the nitrogen atom, some of the examined amides (R = cyclohexyl, phenyl) exist in different conformational forms while other exist only in the transform.

Različiti N-supstituisani 2-fenilbutanamidi formule CH3CH2CH(Ph)CONHR, gde R predstavlja etil, n-butil, i-butil, cikloheksil ifenil grupu, su sintetizovani i definisani temperaturom topljenja, FT-IR, 1H NMR i MS. U zavisnosti od supstituenta na atomu azota, neki od ispitivanih amida se nalaze u različitim konformacionim oblicima (R=cikloheksil, fenil) dok se ostali amidi nalaze samo u trans obliku.