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A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode
dc.creator | Avramov-Ivić, Milka | |
dc.creator | Antanasijević, Jelena | |
dc.creator | Trišović, Nemanja | |
dc.creator | Antanasijević, Davor | |
dc.creator | Lović, Jelena | |
dc.creator | Mijin, Dušan | |
dc.creator | Petrović, Slobodan | |
dc.date.accessioned | 2021-03-10T13:09:01Z | |
dc.date.available | 2021-03-10T13:09:01Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1452-3981 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3358 | |
dc.description.abstract | The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM. | en |
dc.publisher | Electrochemical Science Group, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172060/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172007/RS// | |
dc.rights | openAccess | |
dc.source | International Journal of Electrochemical Science | |
dc.subject | phenobarbital | en |
dc.subject | paracetamol | en |
dc.subject | voltammetry | en |
dc.subject | chemometrics | en |
dc.title | A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 5951 | |
dc.citation.issue | 7 | |
dc.citation.other | 11(7): 5935-5951 | |
dc.citation.rank | M23 | |
dc.citation.spage | 5935 | |
dc.citation.volume | 11 | |
dc.identifier.doi | 10.20964/2016.07.48 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/1280/3355.pdf | |
dc.identifier.scopus | 2-s2.0-84978138152 | |
dc.identifier.wos | 000384905600050 | |
dc.type.version | publishedVersion |