Show simple item record

dc.creatorMihailović-Stanojević, Nevena
dc.creatorMiloradović, Zoran
dc.creatorIvanov, Milan
dc.creatorBugarski, Branko
dc.creatorJovović, Đurđica
dc.creatorKaranović, Danijela
dc.creatorVajić, Una-Jovana
dc.creatorKomes, Drazenka
dc.creatorGrujić-Milanović, Jelica
dc.date.accessioned2021-03-10T13:09:21Z
dc.date.available2021-03-10T13:09:21Z
dc.date.issued2016
dc.identifier.issn1942-0900
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3363
dc.description.abstractHigh blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions.en
dc.publisherHindawi Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceOxidative Medicine and Cellular Longevity
dc.titleUpregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stressen
dc.typearticle
dc.rights.licenseBY
dc.citation.other2016: -
dc.citation.rankM21
dc.citation.volume2016
dc.identifier.doi10.1155/2016/1458793
dc.identifier.pmid27774115
dc.identifier.rcubconv_5112
dc.identifier.scopus2-s2.0-84991387659
dc.identifier.wos000385101300001
dc.type.versionpublishedVersion


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record