Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy
Аутори
Knežević, Nikola Ž.Mrdanović, Jasminka
Borisev, Ivana
Milenković, Sanja
Janaćković, Đorđe
Cunin, Frederique
Đorđević, Aleksandar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces.
Извор:
RSC Advances, 2016, 6, 9, 7061-7065Издавач:
- Royal Society of Chemistry
Финансирање / пројекти:
- Функционални, функционализовани и усавршени нано материјали (RS-45005)
- Синтеза, развој технологија добијања и примена наноструктурних мултифункционалних материјала дефинисаних својстава (RS-45019)
DOI: 10.1039/c5ra22937e
ISSN: 2046-2069
WoS: 000369515500025
Scopus: 2-s2.0-84977261333
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Knežević, Nikola Ž. AU - Mrdanović, Jasminka AU - Borisev, Ivana AU - Milenković, Sanja AU - Janaćković, Đorđe AU - Cunin, Frederique AU - Đorđević, Aleksandar PY - 2016 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3386 AB - A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces. PB - Royal Society of Chemistry T2 - RSC Advances T1 - Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy EP - 7065 IS - 9 SP - 7061 VL - 6 DO - 10.1039/c5ra22937e ER -
@article{ author = "Knežević, Nikola Ž. and Mrdanović, Jasminka and Borisev, Ivana and Milenković, Sanja and Janaćković, Đorđe and Cunin, Frederique and Đorđević, Aleksandar", year = "2016", abstract = "A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces.", publisher = "Royal Society of Chemistry", journal = "RSC Advances", title = "Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy", pages = "7065-7061", number = "9", volume = "6", doi = "10.1039/c5ra22937e" }
Knežević, N. Ž., Mrdanović, J., Borisev, I., Milenković, S., Janaćković, Đ., Cunin, F.,& Đorđević, A.. (2016). Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy. in RSC Advances Royal Society of Chemistry., 6(9), 7061-7065. https://doi.org/10.1039/c5ra22937e
Knežević NŽ, Mrdanović J, Borisev I, Milenković S, Janaćković Đ, Cunin F, Đorđević A. Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy. in RSC Advances. 2016;6(9):7061-7065. doi:10.1039/c5ra22937e .
Knežević, Nikola Ž., Mrdanović, Jasminka, Borisev, Ivana, Milenković, Sanja, Janaćković, Đorđe, Cunin, Frederique, Đorđević, Aleksandar, "Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy" in RSC Advances, 6, no. 9 (2016):7061-7065, https://doi.org/10.1039/c5ra22937e . .