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dc.creatorBabić, Marija
dc.creatorBožić, Bojan
dc.creatorBožić, Biljana
dc.creatorFilipović, Jovanka
dc.creatorUšćumlić, Gordana
dc.creatorTomić, Simonida
dc.date.accessioned2021-03-10T13:12:19Z
dc.date.available2021-03-10T13:12:19Z
dc.date.issued2016
dc.identifier.issn0167-577X
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3409
dc.description.abstractA series of dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA)) hydrogels were synthesized and evaluated as potential highly effective antiproliferative drug delivery system. Investigated hydrophobic antiproliferative agent, Ni(II) complex with Oxaprozin, was successfully synthesized and efficiently loaded into the'"intelligent" P(HPA/IA) hydrogels. Swelling studies showed that loaded agent did not annul pH- and temperature-sensitivity of the investigated hydrogels. In vitro antiproliferative activity of investigated complex against human cervical (HeLa) and melanoma cancer (FemX) cell lines was tested. The results of in vitro release study at different pH values confirmed synthesized hydrogels loaded with investigated complex as a highly effective pH-triggered drug delivery system for the advanced anticancer therapy as well as for the targeted treatment of intestine/colon cancers.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.rightsrestrictedAccess
dc.sourceMaterials Letters
dc.subjectHydrogelen
dc.subjectTransition metal drugen
dc.subjectControlled drug deliveryen
dc.subjectAntiproliferative activityen
dc.titleEvaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozinen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage217
dc.citation.other163: 214-217
dc.citation.rankM22
dc.citation.spage214
dc.citation.volume163
dc.identifier.doi10.1016/j.matlet.2015.10.078
dc.identifier.scopus2-s2.0-84945379542
dc.identifier.wos000366081400054
dc.type.versionpublishedVersion


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