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dc.creatorKostić, Danijela
dc.creatorMalagurski, Ivana
dc.creatorObradović, Bojana
dc.date.accessioned2021-03-10T13:25:24Z
dc.date.available2021-03-10T13:25:24Z
dc.date.issued2017
dc.identifier.issn0367-598X
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3608
dc.description.abstractThe aim of this work was to assess phenomena occurring during AgNP transport from nanocomposite Ag/alginate hydrogels under conditions relevant for potential biomedical applications as antimicrobial soft tissue implants. First, we have studied AgNP migration from the nanocomposite to the adjacent alginate hydrogel mimicking soft tissue next to the implant. AgNP deposition was carried out by the initial burst release lasting for similar to 24 h yielding large aggregates on hydrogel surfaces and smaller clusters (similar to 400 nm in size) inside. However, the overall released content was low (0.67%) indicating high nanocomposite stability. In the next experimental series, release of AgNPs, 10-30 nm in size, from Ag/alginate microbeads in water was investigated under static conditions as well as under continuous perfusion mimicking vascularized tissues. Mathematical modeling has revealed AgNP release by diffusion under static conditions with the diffusion coefficient within the Ag/alginate hydrogel of 6.9x10(-19) m(2) s(-1). Conversely, continuous perfusion induced increased AgNP release by convection with the interstitial fluid velocity estimated as 4.6 nm s(-1). Overall, the obtained results indicated the influence of hydrodynamic conditions at the implantation site on silver release and potential implant functionality, which should be investigated at the experimentation beginning using appropriate in vitro systems.en
dc.publisherSavez hemijskih inženjera, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceHemijska industrija
dc.subjectsilver nanoparticlesen
dc.subjectaggregationen
dc.subjectconvectionen
dc.subjectmathematical modelingen
dc.subjecttissue implantsen
dc.titleTransport of silver nanoparticles from nanocomposite Ag/alginate hydrogels under conditions mimicking tissue implantationen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage394
dc.citation.issue5
dc.citation.other71(5): 383-394
dc.citation.rankM23
dc.citation.spage383
dc.citation.volume71
dc.identifier.doi10.2298/HEMIND160713049K
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/1458/3605.pdf
dc.identifier.rcubconv_5440
dc.identifier.scopus2-s2.0-85035097673
dc.identifier.wos000415092200003
dc.type.versionpublishedVersion


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