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dc.creatorKojić, M.
dc.creatorMilosević, M.
dc.creatorSimić, Vladimir
dc.creatorStojanović, Dušica
dc.creatorUskoković, Petar
dc.date.accessioned2021-03-10T13:27:43Z
dc.date.available2021-03-10T13:27:43Z
dc.date.issued2017
dc.identifier.issn1820-6530
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3644
dc.description.abstractThe aim of this study was to investigate the release performance of an electrospun composite drug loaded nanofiber mat. Electrospun nanofiber mats are promising as drug carriers which offer site-specific delivery of drugs to a target in the human body and may be used for cancer therapy. The authors have formulated a simple radial 1D finite element, which is used to model diffusion within fibers releasing a drug to the surrounding medium discretized by continuum 3D finite elements. The numerical model includes degradation effects and hydrophobicity at the fibers/surroundings interface. For the purpose of experimental investigation, a poly(D, L-lacticco-glycolic acid) (PLGA) implant has been created at the Faculty of Technology and Metallurgy, University of Belgrade. The radial 1D element provides accurate predictions of the diffusion process and serves as an efficient tool for describing transport inside the polymer fiber and surrounding porous medium; which is illustrated through numerical examples.en
dc.publisherUniverzitet u Kragujevcu - Fakultet inženjerskih nauka, Kragujevac
dc.relationCity of Kragujevac, Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/174028/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41007/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Society for Computational Mechanics
dc.subjectRadial 1D finite elementen
dc.subjectdiffusionen
dc.subjectdrug transporten
dc.subjectemulsion electrospinningen
dc.subjectPLGA implantsen
dc.titleA radial 1D Finite Element for Drug Release from Drug Loaded Nanofibersen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage93
dc.citation.issue1
dc.citation.other11(1): 82-93
dc.citation.rankM52
dc.citation.spage82
dc.citation.volume11
dc.identifier.doi10.24874/jsscm.2017.11.01.08
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/1485/3641.pdf
dc.identifier.rcubconv_5479
dc.identifier.scopus2-s2.0-85040786049
dc.identifier.wos000419440000008
dc.type.versionpublishedVersion


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