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dc.creatorPajić-Lijaković, Ivana
dc.creatorMilivojević, Milan
dc.date.accessioned2021-03-10T13:30:23Z
dc.date.available2021-03-10T13:30:23Z
dc.date.issued2017
dc.identifier.issn0092-0606
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3684
dc.description.abstractThe mean features of cell surface rearrangement during cell aggregate rounding after uni-axial compression between parallel plates are considered. This is based on long-time rheological modeling approaches in order to shed further light on collective cell migration. Many aspects of cell migration at the supra-cellular level, such as the coordination between surrounding migrating cell groups that leads to uncorrelated motility, have remained unclear. Aggregate shape changes during rounding are considered depending on the size and homogeneity of 2-D and 3-D cell aggregates. Cell aggregate shape changes that are taking place during successive relaxation cycles have various relaxation rates per cycle. Every relaxation rate is related to the corresponding cell migrating state. If most of the cells migrate per cycle, the relaxation rate is maximal. If most of the cells are in a resting state per cycle, the relaxation rate is nearing zero. If some cell groups migrate while the others, at the same time, stay in a resting state, the relaxation rate is lower than that obtained for the migrating cells. The relaxation rates per cycles are not random, but they have a tendency to gather around two or three values indicating an organized cell migrating pattern. Such behavior suggests that uncorrelated motility during collective cell migration in one cycle induces a decrease of the relaxation rate in the next cycle caused by an accumulation of cells in the resting state. However, cells have the ability to overcome these perturbations and re-establish an ordered migrating trend in the next cycle. These perturbations of the cell migrating state are more pronounced for: (1) more mobile cells, (2) a heterogeneous cell population, and (3) a larger cell population under the same experimental conditions.en
dc.publisherSpringer, Dordrecht
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.rightsopenAccess
dc.sourceJournal of Biological Physics
dc.subjectCell mobility stateen
dc.subjectSuccessive relaxation cyclesen
dc.subjectAggregate long-time relaxationen
dc.subjectConstitutive modelen
dc.titleSuccessive relaxation cycles during long-time cell aggregate rounding after uni-axial compressionen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage209
dc.citation.issue2
dc.citation.other43(2): 197-209
dc.citation.rankM23
dc.citation.spage197
dc.citation.volume43
dc.identifier.doi10.1007/s10867-017-9446-7
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/9582/10867_2017_Article_9446.pdf
dc.identifier.pmid28337554
dc.identifier.scopus2-s2.0-85015909208
dc.identifier.wos000403474900003
dc.type.versionpublishedVersion


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Приказ основних података о документу