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dc.creatorTolić, Ljiljana
dc.creatorGrujić, Svetlana
dc.creatorLaušević, Mila
dc.date.accessioned2021-03-10T13:43:09Z
dc.date.available2021-03-10T13:43:09Z
dc.date.issued2018
dc.identifier.issn1984-8250
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3881
dc.description.abstractMultifunctional drug anisomycin was subjected to forced degradation in accordance with International Conference on Harmonisation (ICH) guidelines for the first time. The drug was exposed to the recommended stress conditions of hydrolysis (acidic, alkaline and neutral), oxidation, thennal stress and photolysis, in order to investigate its stability. Optimized LC-MS/MS method was validated as recommended by ICH Q2(R1) guideline with respect to the specificity, accuracy, precision, limits of detection and quantitation, linearity and robustness. Anisomycin exhibited high instability under alkaline and thermal (neutral hydrolysis) conditions. It showed moderate stability under acidic, neutral, oxidative, thermal (acidic hydrolysis) and photolytic conditions, with the lowest degradation level observed in the case of light and oxidation stress. Formation of the same degradation product, identified as deacetylanisomycin, was observed under all applied stress conditions.en
dc.publisherUniversity of Sao Paulo, Conjunto Quimicas, Sao Paulo
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172007/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceBrazilian Journal of Pharmaceutical Sciences
dc.subjectAnisomycin/forced degradationen
dc.subjectStability-indicatingen
dc.subjectLC-MS/MS/validationen
dc.subjectDeacetylanisomycinen
dc.titleDevelopment and validation of a stability-indicating LC-UV and LC-MS/MS methods for quantitative analysis of anisomycin and identification of degradation productsen
dc.typearticle
dc.rights.licenseBY-NC
dc.citation.issue2
dc.citation.other54(2): -
dc.citation.rankM23
dc.citation.volume54
dc.identifier.doi10.1590/s2175-97902018000217491
dc.identifier.rcubconv_5644
dc.identifier.scopus2-s2.0-85050893254
dc.identifier.wos000440488300001
dc.type.versionpublishedVersion


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