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dc.creatorJovanović, Aleksandra
dc.creatorBalanč, Bojana
dc.creatorĐorđević, Verica
dc.creatorOta, Ajda
dc.creatorSkrt, Mihaela
dc.creatorŠavikin, Katarina
dc.creatorBugarski, Branko
dc.creatorNedović, Viktor
dc.creatorPoklar-Ulrih, Nataša
dc.date.accessioned2021-03-10T13:56:24Z
dc.date.available2021-03-10T13:56:24Z
dc.date.issued2019
dc.identifier.issn0927-7765
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4088
dc.description.abstractMultifunctional liposomes incorporating beta-sitosterol were developed for delivery of gentisic acid (GA). The interactions of both compounds with phospholipid bilayer were interpreted viaeffects of different beta-sitosterol content (0, 20 and 50 mol %) and different gentisic acid to lipid ratio (n(GA)/n(lip) from 10(-5) to 1) on membrane fluidity and thermotropic properties. Multilamellar vesicles of phosphatidylcholines (with size range between 1350 and 1900 nm) effectively encapsulated GA (54%) when n(GA)/n(lip) was higher than 0.01. Suppression of lipid peroxidation was directly related to concentration of GA. The resistance to diffusion of gentisic acid from liposomes increased for (similar to)50% in samples incorporating 50 mol % beta-sitosterol compared to sterol-free liposomes. Finally, simulated in vitro gastrointestinal conditions showed that the release was mainly affected by low pH of simulated gastric fluid and the presence of cholates in simulated intestinal fluid, rather than by enzymes activity.en
dc.publisherElsevier, Amsterdam
dc.relationSlovenian Research AgencySlovenian Research Agency - Slovenia [P4-0121]
dc.relationbilateral project Serbia
dc.relationbilateral project Slovenia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS//
dc.rightsrestrictedAccess
dc.sourceColloids and Surfaces B-Biointerfaces
dc.subjectGentisic aciden
dc.subjectLiposomesen
dc.subjectbeta-sitosterolen
dc.subjectRelease studyen
dc.subjectMembrane fluidityen
dc.subjectPhosphatidylcholinesen
dc.titleEffect of gentisic acid on the structural-functional properties of liposomes incorporating beta-sitosterolen
dc.typearticle
dc.rights.licenseARR
dc.citation.other183: -
dc.citation.rankM21
dc.citation.volume183
dc.identifier.doi10.1016/j.colsurfb.2019.110422
dc.identifier.pmid31437609
dc.identifier.rcubconv_5969
dc.identifier.scopus2-s2.0-85070688519
dc.identifier.wos000494048600029
dc.type.versionpublishedVersion


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