Long-time viscoelasticity of multicellular surfaces caused by collective cell migration - Multi-scale modeling considerations
Само за регистроване кориснике
2019
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Long-time viscoelasticity of multicellular surfaces caused by collective cell migration depends on: (1) the volume fraction and configuration of migrating cells and the rate of its change, (2) the viscoelasticity of migrating cell groups, and (3) the viscoelasticity of surrounding resting cells. The key parameter that influences the viscoelasticity is the size, shape, and thickness of the biointerface between migrating and resting cell sub-populations. The mull-scale nature of the biointerface dynamics represents the product of: (1) the local changes of the size and shape of migrating cell groups, (2) the local accumulation of resistance stress within the core regions of migrating cell groups (internal effects), (3) the collision of the velocity fronts (external effects). The local changes of the size and shape of migrating cell groups induces additional energy dissipation. The accumulated stress could induce disordering of migrating cell groups and consequently migrating-to-resting ce...ll state transition. The collision of the velocity fronts could lead to stagnant zone formation and local increase of the volume fraction of resting cells. Herein, an attempt is made to discuss and connect various modeling approaches from the stand point of thermodynamics and rheology obtained at (1) cellular level, (2) biointerface between migrating cell group and surrounding resting cells, and (3) a part of multicellular surfaces. These complex phenomena are discussed on the model system such as cell aggregate rounding after uni-axial compression under in vitro conditions at characteristic times such as: (1) cell shape relaxation time under stretching/compression, (2) contact time between migrating cell group and surrounding resting cells, (3) cell persistence time, (4) the lifetime of migrating cell groups, (5) cell rearrangement time (i.e. the process time), and (6) the stress and strain relaxation times of perturbed multicellular surface parts. The results of this theoretical analysis point to the relationship between interfacial size, mechanical coupling mode and rheological behavior of multicellular surfaces. Multi scale dynamics at the biointerface is a key parameter which influences mechanical behavior of multicellular surfaces. Consequently, the shape of migrating cell groups and their distribution are not random characteristics of the multicellular surface but rather influenced by cause-consequence relations between biochemical processes at the cellular level and surface stiffness distribution at the mesoscopic level.
Кључне речи:
The viscoelasticity of multicellular surfaces / Collective cell migration / The configurations of migrating cells / Mechanical coupling modes / Multi scale modeling considerationsИзвор:
Seminars in Cell & Developmental Biology, 2019, 93, 87-96Издавач:
- Academic Press Ltd- Elsevier Science Ltd, London
Финансирање / пројекти:
- Развој и примена нових и традиционалних технологија у производњи конкурентних прехрамбених производа са додатом вредношћу за европско и светско тржиште - Створимо богатство из богатства Србије (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
DOI: 10.1016/j.semcdb.2018.08.002
ISSN: 1084-9521
PubMed: 30086376
WoS: 000485036300010
Scopus: 2-s2.0-85051023092
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4089 AB - Long-time viscoelasticity of multicellular surfaces caused by collective cell migration depends on: (1) the volume fraction and configuration of migrating cells and the rate of its change, (2) the viscoelasticity of migrating cell groups, and (3) the viscoelasticity of surrounding resting cells. The key parameter that influences the viscoelasticity is the size, shape, and thickness of the biointerface between migrating and resting cell sub-populations. The mull-scale nature of the biointerface dynamics represents the product of: (1) the local changes of the size and shape of migrating cell groups, (2) the local accumulation of resistance stress within the core regions of migrating cell groups (internal effects), (3) the collision of the velocity fronts (external effects). The local changes of the size and shape of migrating cell groups induces additional energy dissipation. The accumulated stress could induce disordering of migrating cell groups and consequently migrating-to-resting cell state transition. The collision of the velocity fronts could lead to stagnant zone formation and local increase of the volume fraction of resting cells. Herein, an attempt is made to discuss and connect various modeling approaches from the stand point of thermodynamics and rheology obtained at (1) cellular level, (2) biointerface between migrating cell group and surrounding resting cells, and (3) a part of multicellular surfaces. These complex phenomena are discussed on the model system such as cell aggregate rounding after uni-axial compression under in vitro conditions at characteristic times such as: (1) cell shape relaxation time under stretching/compression, (2) contact time between migrating cell group and surrounding resting cells, (3) cell persistence time, (4) the lifetime of migrating cell groups, (5) cell rearrangement time (i.e. the process time), and (6) the stress and strain relaxation times of perturbed multicellular surface parts. The results of this theoretical analysis point to the relationship between interfacial size, mechanical coupling mode and rheological behavior of multicellular surfaces. Multi scale dynamics at the biointerface is a key parameter which influences mechanical behavior of multicellular surfaces. Consequently, the shape of migrating cell groups and their distribution are not random characteristics of the multicellular surface but rather influenced by cause-consequence relations between biochemical processes at the cellular level and surface stiffness distribution at the mesoscopic level. PB - Academic Press Ltd- Elsevier Science Ltd, London T2 - Seminars in Cell & Developmental Biology T1 - Long-time viscoelasticity of multicellular surfaces caused by collective cell migration - Multi-scale modeling considerations EP - 96 SP - 87 VL - 93 DO - 10.1016/j.semcdb.2018.08.002 ER -
@article{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2019", abstract = "Long-time viscoelasticity of multicellular surfaces caused by collective cell migration depends on: (1) the volume fraction and configuration of migrating cells and the rate of its change, (2) the viscoelasticity of migrating cell groups, and (3) the viscoelasticity of surrounding resting cells. The key parameter that influences the viscoelasticity is the size, shape, and thickness of the biointerface between migrating and resting cell sub-populations. The mull-scale nature of the biointerface dynamics represents the product of: (1) the local changes of the size and shape of migrating cell groups, (2) the local accumulation of resistance stress within the core regions of migrating cell groups (internal effects), (3) the collision of the velocity fronts (external effects). The local changes of the size and shape of migrating cell groups induces additional energy dissipation. The accumulated stress could induce disordering of migrating cell groups and consequently migrating-to-resting cell state transition. The collision of the velocity fronts could lead to stagnant zone formation and local increase of the volume fraction of resting cells. Herein, an attempt is made to discuss and connect various modeling approaches from the stand point of thermodynamics and rheology obtained at (1) cellular level, (2) biointerface between migrating cell group and surrounding resting cells, and (3) a part of multicellular surfaces. These complex phenomena are discussed on the model system such as cell aggregate rounding after uni-axial compression under in vitro conditions at characteristic times such as: (1) cell shape relaxation time under stretching/compression, (2) contact time between migrating cell group and surrounding resting cells, (3) cell persistence time, (4) the lifetime of migrating cell groups, (5) cell rearrangement time (i.e. the process time), and (6) the stress and strain relaxation times of perturbed multicellular surface parts. The results of this theoretical analysis point to the relationship between interfacial size, mechanical coupling mode and rheological behavior of multicellular surfaces. Multi scale dynamics at the biointerface is a key parameter which influences mechanical behavior of multicellular surfaces. Consequently, the shape of migrating cell groups and their distribution are not random characteristics of the multicellular surface but rather influenced by cause-consequence relations between biochemical processes at the cellular level and surface stiffness distribution at the mesoscopic level.", publisher = "Academic Press Ltd- Elsevier Science Ltd, London", journal = "Seminars in Cell & Developmental Biology", title = "Long-time viscoelasticity of multicellular surfaces caused by collective cell migration - Multi-scale modeling considerations", pages = "96-87", volume = "93", doi = "10.1016/j.semcdb.2018.08.002" }
Pajić-Lijaković, I.,& Milivojević, M.. (2019). Long-time viscoelasticity of multicellular surfaces caused by collective cell migration - Multi-scale modeling considerations. in Seminars in Cell & Developmental Biology Academic Press Ltd- Elsevier Science Ltd, London., 93, 87-96. https://doi.org/10.1016/j.semcdb.2018.08.002
Pajić-Lijaković I, Milivojević M. Long-time viscoelasticity of multicellular surfaces caused by collective cell migration - Multi-scale modeling considerations. in Seminars in Cell & Developmental Biology. 2019;93:87-96. doi:10.1016/j.semcdb.2018.08.002 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Long-time viscoelasticity of multicellular surfaces caused by collective cell migration - Multi-scale modeling considerations" in Seminars in Cell & Developmental Biology, 93 (2019):87-96, https://doi.org/10.1016/j.semcdb.2018.08.002 . .