Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
2019
Authors
Lović, JelenaLađarević, Jelena
Mijin, Dušan
Jadranin, Milka
Petrović, Slobodan
Avramov-Ivić, Milka
Article (Published version)
Metadata
Show full item recordAbstract
In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.
Keywords:
cyclic voltammetry / square wave voltammetry / Au electrode / GC electrode / IrOX electrode / total organic carbon analysisSource:
Journal of the Serbian Chemical Society, 2019, 84, 11, 1319-1327Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-MESTD-Basic Research (BR or ON)-172013)
- New approach in designing materials for energy conversion and energy storage systems (RS-MESTD-Basic Research (BR or ON)-172060)
DOI: 10.2298/JSC190731091L
ISSN: 0352-5139
WoS: 000500748300011
Scopus: 2-s2.0-85076372324
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Lović, Jelena AU - Lađarević, Jelena AU - Mijin, Dušan AU - Jadranin, Milka AU - Petrović, Slobodan AU - Avramov-Ivić, Milka PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4102 AB - In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes EP - 1327 IS - 11 SP - 1319 VL - 84 DO - 10.2298/JSC190731091L ER -
@article{ author = "Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Jadranin, Milka and Petrović, Slobodan and Avramov-Ivić, Milka", year = "2019", abstract = "In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes", pages = "1327-1319", number = "11", volume = "84", doi = "10.2298/JSC190731091L" }
Lović, J., Lađarević, J., Mijin, D., Jadranin, M., Petrović, S.,& Avramov-Ivić, M.. (2019). Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 84(11), 1319-1327. https://doi.org/10.2298/JSC190731091L
Lović J, Lađarević J, Mijin D, Jadranin M, Petrović S, Avramov-Ivić M. Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society. 2019;84(11):1319-1327. doi:10.2298/JSC190731091L .
Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Jadranin, Milka, Petrović, Slobodan, Avramov-Ivić, Milka, "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1319-1327, https://doi.org/10.2298/JSC190731091L . .