Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles - In vitro study
Само за регистроване кориснике
2019
Аутори
Nešović, KatarinaJanković, Ana
Radetić, Tamara
Vukašinović-Sekulić, Maja
Kojić, Vesna
Živković, Ljiljana
Perić-Grujić, Aleksandra
Rhee, Kyong Yop
Mišković-Stanković, Vesna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this work, we provide a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent. The hydrogels were prepared via freezing-thawing method, whereas AgNPs were synthesized via an in situ electrochemical route. The excellent physicochemical properties of the obtained nanocomposite hydrogels were validated using different spectroscopic and microscopic techniques. The formation of sub-10 nm AgNPs was confirmed by UV-visible spectroscopy, dynamic light scattering and transmission electron microscopy. Swelling and silver release profiles were validated using several diffusion models. The hydrogels were proven to be non-cytotoxic using MTT test and possessed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli, as determined by test in suspension, which affirmed their feasibility for wound ...dressing applications.
Кључне речи:
Chitosan hydrogel / Silver nanoparticles / Antibacterial wound dressings / Release profiles / Swelling kineticsИзвор:
European Polymer Journal, 2019, 121Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Синтеза, развој технологија добијања и примена наноструктурних мултифункционалних материјала дефинисаних својстава (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
- National Research Foundation of the Ministry of Education, Republic of Korea (Basic Science Research Program) [2018R1A2B5A02023190]
DOI: 10.1016/j.eurpolymj.2019.109257
ISSN: 0014-3057
WoS: 000504504800008
Scopus: 2-s2.0-85072807623
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Nešović, Katarina AU - Janković, Ana AU - Radetić, Tamara AU - Vukašinović-Sekulić, Maja AU - Kojić, Vesna AU - Živković, Ljiljana AU - Perić-Grujić, Aleksandra AU - Rhee, Kyong Yop AU - Mišković-Stanković, Vesna PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4113 AB - In this work, we provide a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent. The hydrogels were prepared via freezing-thawing method, whereas AgNPs were synthesized via an in situ electrochemical route. The excellent physicochemical properties of the obtained nanocomposite hydrogels were validated using different spectroscopic and microscopic techniques. The formation of sub-10 nm AgNPs was confirmed by UV-visible spectroscopy, dynamic light scattering and transmission electron microscopy. Swelling and silver release profiles were validated using several diffusion models. The hydrogels were proven to be non-cytotoxic using MTT test and possessed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli, as determined by test in suspension, which affirmed their feasibility for wound dressing applications. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - European Polymer Journal T1 - Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles - In vitro study VL - 121 DO - 10.1016/j.eurpolymj.2019.109257 ER -
@article{ author = "Nešović, Katarina and Janković, Ana and Radetić, Tamara and Vukašinović-Sekulić, Maja and Kojić, Vesna and Živković, Ljiljana and Perić-Grujić, Aleksandra and Rhee, Kyong Yop and Mišković-Stanković, Vesna", year = "2019", abstract = "In this work, we provide a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent. The hydrogels were prepared via freezing-thawing method, whereas AgNPs were synthesized via an in situ electrochemical route. The excellent physicochemical properties of the obtained nanocomposite hydrogels were validated using different spectroscopic and microscopic techniques. The formation of sub-10 nm AgNPs was confirmed by UV-visible spectroscopy, dynamic light scattering and transmission electron microscopy. Swelling and silver release profiles were validated using several diffusion models. The hydrogels were proven to be non-cytotoxic using MTT test and possessed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli, as determined by test in suspension, which affirmed their feasibility for wound dressing applications.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "European Polymer Journal", title = "Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles - In vitro study", volume = "121", doi = "10.1016/j.eurpolymj.2019.109257" }
Nešović, K., Janković, A., Radetić, T., Vukašinović-Sekulić, M., Kojić, V., Živković, L., Perić-Grujić, A., Rhee, K. Y.,& Mišković-Stanković, V.. (2019). Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles - In vitro study. in European Polymer Journal Pergamon-Elsevier Science Ltd, Oxford., 121. https://doi.org/10.1016/j.eurpolymj.2019.109257
Nešović K, Janković A, Radetić T, Vukašinović-Sekulić M, Kojić V, Živković L, Perić-Grujić A, Rhee KY, Mišković-Stanković V. Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles - In vitro study. in European Polymer Journal. 2019;121. doi:10.1016/j.eurpolymj.2019.109257 .
Nešović, Katarina, Janković, Ana, Radetić, Tamara, Vukašinović-Sekulić, Maja, Kojić, Vesna, Živković, Ljiljana, Perić-Grujić, Aleksandra, Rhee, Kyong Yop, Mišković-Stanković, Vesna, "Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles - In vitro study" in European Polymer Journal, 121 (2019), https://doi.org/10.1016/j.eurpolymj.2019.109257 . .