Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin
2019
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Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m(2)/g). The material's surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues.
Ključne reči:
drug delivery / nanocarrier / porous nanoparticles / cancer treatmentIzvor:
Inorganics, 2019, 7, 2Izdavač:
- MDPI, Basel
Finansiranje / projekti:
- Sinteza, razvoj tehnologija dobijanja i primena nanostrukturnih multifunkcionalnih materijala definisanih svojstava (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
- Razvoj novih informaciono-komunikacionih tehnologija, korišćenjem naprednih matematičkih metoda, sa primenama u medicini, telekomunikacijama, energetici, zaštititi nacionalne baštine i obrazovanju (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-44006)
DOI: 10.3390/inorganics7020016
ISSN: 2304-6740
WoS: 000460321800010
Scopus: 2-s2.0-85062146124
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Knežević, Nikola Ž. AU - Đorđević, Sanja AU - Kojić, Vesna AU - Janaćković, Đorđe PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4156 AB - Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m(2)/g). The material's surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues. PB - MDPI, Basel T2 - Inorganics T1 - Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin IS - 2 VL - 7 DO - 10.3390/inorganics7020016 ER -
@article{ author = "Knežević, Nikola Ž. and Đorđević, Sanja and Kojić, Vesna and Janaćković, Đorđe", year = "2019", abstract = "Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m(2)/g). The material's surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues.", publisher = "MDPI, Basel", journal = "Inorganics", title = "Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin", number = "2", volume = "7", doi = "10.3390/inorganics7020016" }
Knežević, N. Ž., Đorđević, S., Kojić, V.,& Janaćković, Đ.. (2019). Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin. in Inorganics MDPI, Basel., 7(2). https://doi.org/10.3390/inorganics7020016
Knežević NŽ, Đorđević S, Kojić V, Janaćković Đ. Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin. in Inorganics. 2019;7(2). doi:10.3390/inorganics7020016 .
Knežević, Nikola Ž., Đorđević, Sanja, Kojić, Vesna, Janaćković, Đorđe, "Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin" in Inorganics, 7, no. 2 (2019), https://doi.org/10.3390/inorganics7020016 . .