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Matrix resistance stress reduction-prerequisite for achieving higher concentration of immobilized cells

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Authors
Pajić-Lijaković, Ivana
Milivojević, Milan
Lević, Steva
Trifković, Kata T.
Balanč, Bojana
Nedović, Viktor
Stevanović-Dajić, Zora
Radosević, Radenko
Bugarski, Branko
Article (Published version)
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Abstract
Some of the main rheological properties that Ca-alginate hydrogel matrix should satisfy for biomedical and biotechnological applications are the matrix viscoelasticity and the ability of stress relaxation. Although alginate satisfies both of them, experimental data note that cell growth is significantly reduced by microenvironmental effects. Microenvironmental restriction effects are connected to matrix resistance stress accumulation. Matrix stress is generated within the boundary layers around the cell aggregates under compression caused by cell rearrangement and growth. Simultaneously induced relaxation phenomena of both subsystems: (1) immobilized cells and (2) hydrogel matrix occur at three time scales through successive relaxation cycles. Complex dynamics of matrix compression intensifies mechanical and electrostatic cell-matrix interactions. Minimizing of the resistance stress is the strategy for improving the matrix performances. Cell action could be simulated in the experiments... without cells during repeated stress relaxation cycles. We consider the physical and chemical modifications of Ca-alginate hydrogel.

Keywords:
Bioprocess optimization / Hydrogel matrix / Immobilized cells / Mathematical modeling / Matrix resistance stress
Source:
Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications, 2019, 281-306

DOI: 10.1016/B978-0-12-818431-8.00009-X

PubMed:

Scopus: 2-s2.0-85094580424
[ Google Scholar ]
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4162
Collections
  • Radovi istraživača (Inovacioni centar) / Researchers’ publications (Innovation Centre)
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Milivojević, Milan
AU  - Lević, Steva
AU  - Trifković, Kata T.
AU  - Balanč, Bojana
AU  - Nedović, Viktor
AU  - Stevanović-Dajić, Zora
AU  - Radosević, Radenko
AU  - Bugarski, Branko
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4162
AB  - Some of the main rheological properties that Ca-alginate hydrogel matrix should satisfy for biomedical and biotechnological applications are the matrix viscoelasticity and the ability of stress relaxation. Although alginate satisfies both of them, experimental data note that cell growth is significantly reduced by microenvironmental effects. Microenvironmental restriction effects are connected to matrix resistance stress accumulation. Matrix stress is generated within the boundary layers around the cell aggregates under compression caused by cell rearrangement and growth. Simultaneously induced relaxation phenomena of both subsystems: (1) immobilized cells and (2) hydrogel matrix occur at three time scales through successive relaxation cycles. Complex dynamics of matrix compression intensifies mechanical and electrostatic cell-matrix interactions. Minimizing of the resistance stress is the strategy for improving the matrix performances. Cell action could be simulated in the experiments without cells during repeated stress relaxation cycles. We consider the physical and chemical modifications of Ca-alginate hydrogel.
T2  - Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications
T1  - Matrix resistance stress reduction-prerequisite for achieving higher concentration of immobilized cells
EP  - 306
SP  - 281
DO  - 10.1016/B978-0-12-818431-8.00009-X
UR  - conv_6421
ER  - 
@article{
author = "Pajić-Lijaković, Ivana and Milivojević, Milan and Lević, Steva and Trifković, Kata T. and Balanč, Bojana and Nedović, Viktor and Stevanović-Dajić, Zora and Radosević, Radenko and Bugarski, Branko",
year = "2019",
abstract = "Some of the main rheological properties that Ca-alginate hydrogel matrix should satisfy for biomedical and biotechnological applications are the matrix viscoelasticity and the ability of stress relaxation. Although alginate satisfies both of them, experimental data note that cell growth is significantly reduced by microenvironmental effects. Microenvironmental restriction effects are connected to matrix resistance stress accumulation. Matrix stress is generated within the boundary layers around the cell aggregates under compression caused by cell rearrangement and growth. Simultaneously induced relaxation phenomena of both subsystems: (1) immobilized cells and (2) hydrogel matrix occur at three time scales through successive relaxation cycles. Complex dynamics of matrix compression intensifies mechanical and electrostatic cell-matrix interactions. Minimizing of the resistance stress is the strategy for improving the matrix performances. Cell action could be simulated in the experiments without cells during repeated stress relaxation cycles. We consider the physical and chemical modifications of Ca-alginate hydrogel.",
journal = "Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications",
title = "Matrix resistance stress reduction-prerequisite for achieving higher concentration of immobilized cells",
pages = "306-281",
doi = "10.1016/B978-0-12-818431-8.00009-X",
url = "conv_6421"
}
Pajić-Lijaković, I., Milivojević, M., Lević, S., Trifković, K. T., Balanč, B., Nedović, V., Stevanović-Dajić, Z., Radosević, R.,& Bugarski, B.. (2019). Matrix resistance stress reduction-prerequisite for achieving higher concentration of immobilized cells. in Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications, 281-306.
https://doi.org/10.1016/B978-0-12-818431-8.00009-X
conv_6421
Pajić-Lijaković I, Milivojević M, Lević S, Trifković KT, Balanč B, Nedović V, Stevanović-Dajić Z, Radosević R, Bugarski B. Matrix resistance stress reduction-prerequisite for achieving higher concentration of immobilized cells. in Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications. 2019;:281-306.
doi:10.1016/B978-0-12-818431-8.00009-X
conv_6421 .
Pajić-Lijaković, Ivana, Milivojević, Milan, Lević, Steva, Trifković, Kata T., Balanč, Bojana, Nedović, Viktor, Stevanović-Dajić, Zora, Radosević, Radenko, Bugarski, Branko, "Matrix resistance stress reduction-prerequisite for achieving higher concentration of immobilized cells" in Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications (2019):281-306,
https://doi.org/10.1016/B978-0-12-818431-8.00009-X .,
conv_6421 .

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