TechnoRep - Faculty of Technology and Metallurgy Repository
University of Belgrade - Faculty of Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones

Thumbnail
2019
0352-51391800092T.pdf (937.0Kb)
Authors
Tadić, Julijana
Mihajlović, Marina
Jovanović, Mica
Mijin, Dušan
Article (Published version)
Metadata
Show full item record
Abstract
In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, H-1-NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.
Keywords:
microreactor / 2-pyridone / batch / flow synthesis / process intensification
Source:
Journal of the Serbian Chemical Society, 2019, 84, 6, 531-538
Publisher:
  • Srpsko hemijsko društvo, Beograd
Funding / projects:
  • Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
  • Cleaner production: power plant wastewater treatment process development (RS-34009)

DOI: 10.2298/JSC180703092T

ISSN: 0352-5139

WoS: 000474347000001

Scopus: 2-s2.0-85071225030
[ Google Scholar ]
2
1
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4234
Collections
  • Radovi istraživača (Inovacioni centar) / Researchers’ publications (Innovation Centre)
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Tadić, Julijana
AU  - Mihajlović, Marina
AU  - Jovanović, Mica
AU  - Mijin, Dušan
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4234
AB  - In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, H-1-NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones
EP  - 538
IS  - 6
SP  - 531
VL  - 84
DO  - 10.2298/JSC180703092T
UR  - conv_5886
ER  - 
@article{
author = "Tadić, Julijana and Mihajlović, Marina and Jovanović, Mica and Mijin, Dušan",
year = "2019",
abstract = "In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, H-1-NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones",
pages = "538-531",
number = "6",
volume = "84",
doi = "10.2298/JSC180703092T",
url = "conv_5886"
}
Tadić, J., Mihajlović, M., Jovanović, M.,& Mijin, D.. (2019). Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 84(6), 531-538.
https://doi.org/10.2298/JSC180703092T
conv_5886
Tadić J, Mihajlović M, Jovanović M, Mijin D. Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones. in Journal of the Serbian Chemical Society. 2019;84(6):531-538.
doi:10.2298/JSC180703092T
conv_5886 .
Tadić, Julijana, Mihajlović, Marina, Jovanović, Mica, Mijin, Dušan, "Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones" in Journal of the Serbian Chemical Society, 84, no. 6 (2019):531-538,
https://doi.org/10.2298/JSC180703092T .,
conv_5886 .

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB