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Fluorimetrijska analiza permeabilnosti lipozomalnih membrana

dc.creatorJovanović, Aleksandra
dc.creatorBalanč, Bojana
dc.creatorĐorđević, Verica
dc.creatorŠavikin, Katarina
dc.creatorNedović, Viktor
dc.creatorBugarski, Branko
dc.creatorPoklar-Ulrih, Nataša
dc.date.accessioned2021-03-10T14:10:14Z
dc.date.available2021-03-10T14:10:14Z
dc.date.issued2019
dc.identifier.issn0040-2176
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4302
dc.description.abstractThe present study provides insight into changes in the liposomal membrane fluidity as a result of variation of structural components (two types of standard phospholipids - 1,2-dipalmitoyl-sn-glycerero3-phosphocholine, i.e. DPPC and 1-palmitoyl-2-oleoylglycerol-3-phosphocholine, i.e. POPC, one type of phospholipid mixture - Lipoid H and sterols - cholesterol and b-sitosterol), as well as variation in sterol concentration (5-50%). Fluorescence spectroscopy (anisotropy, r) has shown that DPPC liposomal membranes were more rigid compared to POPC and Lipoid H lipid bilayers. Furthermore, the increment of sterol concentration has caused a decrease in the membrane fluidity in all liposomal samples. On the other hand, phospholipid bilayers containing b-sitosterol has possessed better fluidity in comparison to their cholesterol parallels. Higher permeability of b-sitosterol liposomal membranes, as well as the beneficial effects of phytosterol on human health, favor the use of b-sitosterol in the preparation of liposomes as components of food, pharmaceutical and cosmetic products.en
dc.description.abstractPrikazana studija daje uvid u promene fluidnosti lipozomalne membrane koje nastaju kao posledica promene strukturnih komponenata lipozoma (dve vrste standardnih fosfolipida - 1,2-dipalmitoil-snglicero-3-fosfoholin, odnosno DPPC i 1-palmitoil-2-oleoil-sn-glicero-3-fosfoholin, odnosno POPC, jedne vrste komercijalne fosfolipidne smeše - Lipoid H i sterola - holesterol i b-sitosterol), kao i promene udela sterola (0-50 mol %). Fluorimetrijska spektrofotometrija (anizotropija, r) pokazala je da su DPPC lipozomalne membrane bile rigidnije u poređenju sa POPC i Lipoid H lipidnim dvoslojima. Pored toga, povećenje koncentracije sterola prouzrokovalo je smanjenje permeabilnosti membrane u svim lipozomima. Sa druge strane, fosfolipidni dvosloji koji su sadržali b-sitosterol pokazali su veću fluidnost u poređenju sa njihovim paralelama sa holesterolom. Bolja permeabilnost b-sitosterol lipozomalnih membrana, kao i blagotvorni uticaji fitosterola na zdravlje ljudi favorizuju primenu b-sitosterola u pripremi lipozoma kao sastavnih delova prehrambenih, farmaceutskih i kozmetičkih proizvoda.sr
dc.publisherSavez inženjera i tehničara Srbije, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceTehnika
dc.subjectb-sitosterolen
dc.subjectliposomesen
dc.subjectpermeabilityen
dc.subjectfluorescence spectroscopyen
dc.subjectcholesterolen
dc.subjectb-sitosterolsr
dc.subjectlipozomisr
dc.subjectpermeabilnostsr
dc.subjectfluorimetrijska spektrofotometrijasr
dc.subjectholesterolsr
dc.titleFluorescence analysis of liposomal membranes permeabilityen
dc.titleFluorimetrijska analiza permeabilnosti lipozomalnih membranasr
dc.typearticle
dc.rights.licenseBY
dc.citation.epage498
dc.citation.issue4
dc.citation.other74(4): 493-498
dc.citation.rankM51
dc.citation.spage493
dc.citation.volume74
dc.identifier.doi10.5937/tehnika1904493J
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/10052/0040-21761904493J.pdf
dc.type.versionpublishedVersion


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