Show simple item record

dc.creatorBarbara, Giovanni
dc.creatorGrover, Madhusudan
dc.creatorBercik, Premysl
dc.creatorCorsetti, Maura
dc.creatorGhoshal, Uday C.
dc.creatorOhman, Lena
dc.creatorRajilić-Stojanović, Mirjana
dc.date.accessioned2021-03-10T14:11:30Z
dc.date.available2021-03-10T14:11:30Z
dc.date.issued2019
dc.identifier.issn0016-5085
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4322
dc.description.abstractBACKGROUND & AIMS: The existence of postinfection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized, and there is little guidance for diagnosis and treatment of PI-IBS. The ROME Foundation has produced a working team report to summarize the available evidence on the pathophysiology of PI-IBS and provide guidance for diagnosis and treatment, based on findings reported in the literature and clinical experience. METHODS: The working team conducted an evidence-based review of publication databases for articles describing the clinical features (diagnosis), pathophysiology (intestinal sensorimotor function, microbiota, immune dysregulation, barrier dysfunction, enteroendocrine pathways, and genetics), and animal models of PI-IBS. We used a Delphi-based consensus system to create guidelines for management of PI-IBS and a developed treatment algorithm based on published findings and experiences of team members. RESULTS: PI-IBS develops in about 10% of patients with infectious enteritis. Risk factors include female sex, younger age, psychological distress during or before acute gastroenteritis, and severity of the acute episode. The pathogenesis of PI-PBS appears to involve changes in the intestinal microbiome as well as epithelial, serotonergic, and immune system factors. However, these mechanisms are incompletely understood. There are no evidence-based, effective pharmacologic strategies for treatment of PI-IBS. We provide a consensus-based treatment algorithm, based on clinical presentation and potential disease mechanisms. CONCLUSIONS: Based on a systematic review of the literature and team experience, we summarize the clinical features, pathophysiology (from animal models and human studies), and progression of PI-IBS. Based on these findings, we present an algorithm for diagnosis and treatment of PI-IBS based on team consensus. We also propose areas for future investigation.en
dc.publisherW B Saunders Co-Elsevier Inc, Philadelphia
dc.relationRome Foundation, North Carolina
dc.relationItalian Ministry of Education, University and ResearchMinistry of Education, Universities and Research (MIUR)
dc.relationFondazione del Monte di Bologna e RavennaFondazione del Monte di Bologna e Ravenna
dc.relationNational Institute of Diabetes and Digestive and Kidney DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [K23 103911]
dc.relationIMA
dc.relationNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [K23DK103911, K23DK103911,
dc.rightsopenAccess
dc.sourceGastroenterology
dc.subjectGastrointestinal Infectionen
dc.subjectMicrobiomeen
dc.subjectCampylobacteren
dc.subjectSerotoninen
dc.subjectBarrier Functionen
dc.titleRome Foundation Working Team Report on Post-Infection Irritable Bowel Syndromeen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage+
dc.citation.issue1
dc.citation.other156(1): 46-+
dc.citation.rankaM21
dc.citation.spage46
dc.citation.volume156
dc.identifier.doi10.1053/j.gastro.2018.07.011
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/1957/4319.pdf
dc.identifier.pmid30009817
dc.identifier.rcubconv_5732
dc.identifier.scopus2-s2.0-85058475069
dc.identifier.wos000453401000021
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record