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dc.creatorVuković, Jovana
dc.creatorPerić-Grujić, Aleksandra
dc.creatorMitić-Culafić, Dragana S.
dc.creatorBožić-Nedeljković, Biljana
dc.creatorTomić, Simonida
dc.date.accessioned2021-03-10T14:12:59Z
dc.date.available2021-03-10T14:12:59Z
dc.date.issued2020
dc.identifier.issn1598-5032
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4345
dc.description.abstractSince the management of infections becomes prior global healthcare issue, the "post antibiotic era" requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 degrees C. Results confirmed the expected structure, while the glass transition temperatures (T-g) of the hydrogels were detected in range of 10-37 degrees C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Comet assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.en
dc.publisherPolymer Soc Korea, Seoul
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsrestrictedAccess
dc.sourceMacromolecular Research
dc.subjecthydrogelen
dc.subject2-hydroxyethyl acrylateen
dc.subjectsilveren
dc.subjectantibacterial activityen
dc.subjectmethicillin resistant Staphylococcus aureus (MRSA)en
dc.titleAntibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogelsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage389
dc.citation.issue4
dc.citation.other28(4): 382-389
dc.citation.rankM22
dc.citation.spage382
dc.citation.volume28
dc.identifier.doi10.1007/s13233-020-8050-z
dc.identifier.scopus2-s2.0-85075654961
dc.identifier.wos000498995300001
dc.type.versionpublishedVersion


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Приказ основних података о документу