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dc.creatorBabić, Marija
dc.creatorVukomanović, Marija
dc.creatorStefanić, Martin
dc.creatorNikodinović-Runić, Jasmina
dc.creatorTomić, Simonida
dc.date.accessioned2021-03-10T14:13:48Z
dc.date.available2021-03-10T14:13:48Z
dc.date.issued2020
dc.identifier.issn1022-1352
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4358
dc.description.abstractThe strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications.en
dc.publisherWiley-VCH Verlag Gmbh, Weinheim
dc.relationSCOPES program of the Swiss National Science Foundation (SNSF)Swiss National Science Foundation (SNSF)
dc.relationSwiss Agency for Development and Cooperation (SDC) [IZ73ZO_152327]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsrestrictedAccess
dc.sourceMacromolecular Chemistry and Physics
dc.subject2-hydroxyethyl methacrylateen
dc.subjectgelatinen
dc.subjectalginateen
dc.subjectiron(III) oxide based hydrogelsen
dc.subjectcontrolled curcumin releaseen
dc.subjectdegradable scaffoldsen
dc.subjectscaffolding biomaterialsen
dc.titleControlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxideen
dc.typearticle
dc.rights.licenseARR
dc.citation.issue20
dc.citation.other221(20): -
dc.citation.rankM22~
dc.citation.volume221
dc.identifier.doi10.1002/macp.202000186
dc.identifier.rcubconv_6211
dc.identifier.scopus2-s2.0-85091348146
dc.identifier.wos000572182800001
dc.type.versionpublishedVersion


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