A survey on the characterization and biological activity of isatin derivatives
Abstract
The derivatives of isatin have already been known to display a variety of biological activities. Therefore, the studies on their activity and its relation to structure have recently become a popular subject for investigation. The examined compounds were synthesized by the reaction of isatin and substituted primary amines and characterized by spectroscopic methods. The investigation of the antimicrobial and antioxidative activity of the synthesized compounds was performed by broth microdilution method. As for the characterization of the investigated isatin based Schiff bases, the linear solvation energy relationships (LSER) were used to analyze the solvent influence on the UV absorption maxima shifts (V-max), using the well known Kamlet-Taft model and taking geometrical isomers into consideration when possible. Linear free energy relationships (LFER) were used to analyze substituent effect on pK(a), as well as NMR chemical shifts and v max values. The antimicrobial activity and characte...rization were related using both experimental and theoretical methods.
Keywords:
antimicrobial activity / E/Z isomers / solvent effects / substituent effects / TD-DFT / 3D QSARSource:
Journal of the Serbian Chemical Society, 2020, 85, 8, 979-1000Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
DOI: 10.2298/JSC200320020D
ISSN: 0352-5139
WoS: 000573968200001
Scopus: 2-s2.0-85091461650
Collections
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Drmanić, Saša AU - Petrović, Predrag AU - Brkić, Dominik R. AU - Marinković, Aleksandar AU - Nikolić, Jasmina PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4366 AB - The derivatives of isatin have already been known to display a variety of biological activities. Therefore, the studies on their activity and its relation to structure have recently become a popular subject for investigation. The examined compounds were synthesized by the reaction of isatin and substituted primary amines and characterized by spectroscopic methods. The investigation of the antimicrobial and antioxidative activity of the synthesized compounds was performed by broth microdilution method. As for the characterization of the investigated isatin based Schiff bases, the linear solvation energy relationships (LSER) were used to analyze the solvent influence on the UV absorption maxima shifts (V-max), using the well known Kamlet-Taft model and taking geometrical isomers into consideration when possible. Linear free energy relationships (LFER) were used to analyze substituent effect on pK(a), as well as NMR chemical shifts and v max values. The antimicrobial activity and characterization were related using both experimental and theoretical methods. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - A survey on the characterization and biological activity of isatin derivatives EP - 1000 IS - 8 SP - 979 VL - 85 DO - 10.2298/JSC200320020D ER -
@article{ author = "Drmanić, Saša and Petrović, Predrag and Brkić, Dominik R. and Marinković, Aleksandar and Nikolić, Jasmina", year = "2020", abstract = "The derivatives of isatin have already been known to display a variety of biological activities. Therefore, the studies on their activity and its relation to structure have recently become a popular subject for investigation. The examined compounds were synthesized by the reaction of isatin and substituted primary amines and characterized by spectroscopic methods. The investigation of the antimicrobial and antioxidative activity of the synthesized compounds was performed by broth microdilution method. As for the characterization of the investigated isatin based Schiff bases, the linear solvation energy relationships (LSER) were used to analyze the solvent influence on the UV absorption maxima shifts (V-max), using the well known Kamlet-Taft model and taking geometrical isomers into consideration when possible. Linear free energy relationships (LFER) were used to analyze substituent effect on pK(a), as well as NMR chemical shifts and v max values. The antimicrobial activity and characterization were related using both experimental and theoretical methods.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "A survey on the characterization and biological activity of isatin derivatives", pages = "1000-979", number = "8", volume = "85", doi = "10.2298/JSC200320020D" }
Drmanić, S., Petrović, P., Brkić, D. R., Marinković, A.,& Nikolić, J.. (2020). A survey on the characterization and biological activity of isatin derivatives. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 85(8), 979-1000. https://doi.org/10.2298/JSC200320020D
Drmanić S, Petrović P, Brkić DR, Marinković A, Nikolić J. A survey on the characterization and biological activity of isatin derivatives. in Journal of the Serbian Chemical Society. 2020;85(8):979-1000. doi:10.2298/JSC200320020D .
Drmanić, Saša, Petrović, Predrag, Brkić, Dominik R., Marinković, Aleksandar, Nikolić, Jasmina, "A survey on the characterization and biological activity of isatin derivatives" in Journal of the Serbian Chemical Society, 85, no. 8 (2020):979-1000, https://doi.org/10.2298/JSC200320020D . .