alpha-Tricalcium phosphate/fluorapatite based composite cements: Synthesis, mechanical properties, and biocompatibility
Само за регистроване кориснике
2020
Аутори
Kazuz, A.Radovanović, Željko
Veljović, Đorđe
Kojić, Vesna
Miletić, Vesna
Petrović, Rada
Janaćković, Đorđe
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Composite cements based on alpha-tricalcium phosphate (alpha-TCP) and nanostructured fluorapatite (FAp), alpha-TCP/FAp, appropriate for dental usage as root canal filling material, have been prepared with the improved mechanical properties and biocompatibility. The influence of FAp concentration on the composite cement properties was investigated. The processing conditions for FAp powders synthesis were optimized and the powder with optimal properties was chosen to obtain alpha-TCP/FAp composite types of cement alpha-TCP powder was prepared by calcination of hydrothermally synthesized hydroxyapatite (HAp) at 1500 degrees C for 2 h. Morphology and phase composition of powders were investigated by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and energy dispersive X-ray spectroscopy (EDS). Soaking of alpha-TCP/FAp specimens in simulated body fluid (SBF) affected the successful transformation of alpha-TCP in...to HAp, while the compressive test revealed the influence of this transformation and FAp content on the mechanical properties of the composites. Specimen containing 5% of FAp after 10 days in SBF showed the highest compressive strength. In vitro MIT and DET biocompatibility tests, performed in the culture of MRC-5 human fibroblast cells, revealed that alpha-TCP/FAp had no cytotoxic effect. These initial findings showed that alpha-TCP/FAp composite cements could yield favorable mechanical properties with no adverse effect on biocompatibility.
Кључне речи:
Composites / Mechanical properties / Apatite / Biomedical applicationsИзвор:
Ceramics International, 2020, 46, 16Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Синтеза, развој технологија добијања и примена наноструктурних мултифункционалних материјала дефинисаних својстава (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
- Развој и примена метода и материјала за мониторинг нових загађујућих и токсичних органских материја и тешких метала (RS-MESTD-Basic Research (BR or ON)-172007)
DOI: 10.1016/j.ceramint.2020.06.301
ISSN: 0272-8842
WoS: 000577305900008
Scopus: 2-s2.0-85087733250
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Kazuz, A. AU - Radovanović, Željko AU - Veljović, Đorđe AU - Kojić, Vesna AU - Miletić, Vesna AU - Petrović, Rada AU - Janaćković, Đorđe PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4371 AB - Composite cements based on alpha-tricalcium phosphate (alpha-TCP) and nanostructured fluorapatite (FAp), alpha-TCP/FAp, appropriate for dental usage as root canal filling material, have been prepared with the improved mechanical properties and biocompatibility. The influence of FAp concentration on the composite cement properties was investigated. The processing conditions for FAp powders synthesis were optimized and the powder with optimal properties was chosen to obtain alpha-TCP/FAp composite types of cement alpha-TCP powder was prepared by calcination of hydrothermally synthesized hydroxyapatite (HAp) at 1500 degrees C for 2 h. Morphology and phase composition of powders were investigated by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and energy dispersive X-ray spectroscopy (EDS). Soaking of alpha-TCP/FAp specimens in simulated body fluid (SBF) affected the successful transformation of alpha-TCP into HAp, while the compressive test revealed the influence of this transformation and FAp content on the mechanical properties of the composites. Specimen containing 5% of FAp after 10 days in SBF showed the highest compressive strength. In vitro MIT and DET biocompatibility tests, performed in the culture of MRC-5 human fibroblast cells, revealed that alpha-TCP/FAp had no cytotoxic effect. These initial findings showed that alpha-TCP/FAp composite cements could yield favorable mechanical properties with no adverse effect on biocompatibility. PB - Elsevier Sci Ltd, Oxford T2 - Ceramics International T1 - alpha-Tricalcium phosphate/fluorapatite based composite cements: Synthesis, mechanical properties, and biocompatibility IS - 16 VL - 46 DO - 10.1016/j.ceramint.2020.06.301 ER -
@article{ author = "Kazuz, A. and Radovanović, Željko and Veljović, Đorđe and Kojić, Vesna and Miletić, Vesna and Petrović, Rada and Janaćković, Đorđe", year = "2020", abstract = "Composite cements based on alpha-tricalcium phosphate (alpha-TCP) and nanostructured fluorapatite (FAp), alpha-TCP/FAp, appropriate for dental usage as root canal filling material, have been prepared with the improved mechanical properties and biocompatibility. The influence of FAp concentration on the composite cement properties was investigated. The processing conditions for FAp powders synthesis were optimized and the powder with optimal properties was chosen to obtain alpha-TCP/FAp composite types of cement alpha-TCP powder was prepared by calcination of hydrothermally synthesized hydroxyapatite (HAp) at 1500 degrees C for 2 h. Morphology and phase composition of powders were investigated by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and energy dispersive X-ray spectroscopy (EDS). Soaking of alpha-TCP/FAp specimens in simulated body fluid (SBF) affected the successful transformation of alpha-TCP into HAp, while the compressive test revealed the influence of this transformation and FAp content on the mechanical properties of the composites. Specimen containing 5% of FAp after 10 days in SBF showed the highest compressive strength. In vitro MIT and DET biocompatibility tests, performed in the culture of MRC-5 human fibroblast cells, revealed that alpha-TCP/FAp had no cytotoxic effect. These initial findings showed that alpha-TCP/FAp composite cements could yield favorable mechanical properties with no adverse effect on biocompatibility.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Ceramics International", title = "alpha-Tricalcium phosphate/fluorapatite based composite cements: Synthesis, mechanical properties, and biocompatibility", number = "16", volume = "46", doi = "10.1016/j.ceramint.2020.06.301" }
Kazuz, A., Radovanović, Ž., Veljović, Đ., Kojić, V., Miletić, V., Petrović, R.,& Janaćković, Đ.. (2020). alpha-Tricalcium phosphate/fluorapatite based composite cements: Synthesis, mechanical properties, and biocompatibility. in Ceramics International Elsevier Sci Ltd, Oxford., 46(16). https://doi.org/10.1016/j.ceramint.2020.06.301
Kazuz A, Radovanović Ž, Veljović Đ, Kojić V, Miletić V, Petrović R, Janaćković Đ. alpha-Tricalcium phosphate/fluorapatite based composite cements: Synthesis, mechanical properties, and biocompatibility. in Ceramics International. 2020;46(16). doi:10.1016/j.ceramint.2020.06.301 .
Kazuz, A., Radovanović, Željko, Veljović, Đorđe, Kojić, Vesna, Miletić, Vesna, Petrović, Rada, Janaćković, Đorđe, "alpha-Tricalcium phosphate/fluorapatite based composite cements: Synthesis, mechanical properties, and biocompatibility" in Ceramics International, 46, no. 16 (2020), https://doi.org/10.1016/j.ceramint.2020.06.301 . .