Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
Authors
Milosević, MiljanStojanović, Dušica
Simić, Vladimir
Grković, Mirjana
Bjelović, Miloš
Uskoković, Petar
Kojić, Miloš
Article (Published version)
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The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(epsilon -caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface.... The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy.
Source:
Scientific Reports, 2020, 10, 1Publisher:
- Nature Publishing Group, London
Funding / projects:
- SILICOFCM - In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy (EU-777204)
- PROMIS, Science Fund of the Republic of Serbia
- City of Kragujevac, Serbia
- Multiscale Methods and Their Applicatios in Nanomedicine (RS-174028)
- Application of biomedical engineering for preclinical and clinical practice (RS-41007)
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
DOI: 10.1038/s41598-020-68117-9
ISSN: 2045-2322
PubMed: 32636450
WoS: 000562324000004
Scopus: 2-s2.0-85087481779
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Milosević, Miljan AU - Stojanović, Dušica AU - Simić, Vladimir AU - Grković, Mirjana AU - Bjelović, Miloš AU - Uskoković, Petar AU - Kojić, Miloš PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4388 AB - The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(epsilon -caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface. The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy. PB - Nature Publishing Group, London T2 - Scientific Reports T1 - Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release IS - 1 VL - 10 DO - 10.1038/s41598-020-68117-9 ER -
@article{ author = "Milosević, Miljan and Stojanović, Dušica and Simić, Vladimir and Grković, Mirjana and Bjelović, Miloš and Uskoković, Petar and Kojić, Miloš", year = "2020", abstract = "The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(epsilon -caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface. The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy.", publisher = "Nature Publishing Group, London", journal = "Scientific Reports", title = "Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release", number = "1", volume = "10", doi = "10.1038/s41598-020-68117-9" }
Milosević, M., Stojanović, D., Simić, V., Grković, M., Bjelović, M., Uskoković, P.,& Kojić, M.. (2020). Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release. in Scientific Reports Nature Publishing Group, London., 10(1). https://doi.org/10.1038/s41598-020-68117-9
Milosević M, Stojanović D, Simić V, Grković M, Bjelović M, Uskoković P, Kojić M. Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release. in Scientific Reports. 2020;10(1). doi:10.1038/s41598-020-68117-9 .
Milosević, Miljan, Stojanović, Dušica, Simić, Vladimir, Grković, Mirjana, Bjelović, Miloš, Uskoković, Petar, Kojić, Miloš, "Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release" in Scientific Reports, 10, no. 1 (2020), https://doi.org/10.1038/s41598-020-68117-9 . .