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dc.creatorVajdle, Olga
dc.creatorŠekuljica, Sanja
dc.creatorGuzsvány, Valéria
dc.creatorNagy, László
dc.creatorKónya, Zoltán
dc.creatorAvramov-Ivić, Milka
dc.creatorMijin, Dušan
dc.creatorPetrović, Slobodan
dc.creatorAnojčić, Jasmina
dc.date.accessioned2021-03-10T14:15:56Z
dc.date.available2021-03-10T14:15:56Z
dc.date.issued2020
dc.identifier.issn1572-6657
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4392
dc.description.abstractIn this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.en
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200125/RS//
dc.relationCEEPUSIII network [CZ-0212-131920]
dc.relation.isversionofhttp://technorep.tmf.bg.ac.rs/handle/123456789/4726
dc.rightsrestrictedAccess
dc.sourceJournal of Electroanalytical Chemistry
dc.subjectMacrolide antibioticsen
dc.subjectSquare wave voltammetryen
dc.subjectCarbon paste electrodeen
dc.subjectGold nanoparticlesen
dc.subjectPharmaceutical preparationsen
dc.titleUse of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparationsen
dc.typearticle
dc.rights.licenseARR
dc.citation.other873: -
dc.citation.rankM21
dc.citation.spage114324
dc.citation.volume873
dc.description.otherPeer-reviewed manuscript: [http://technorep.tmf.bg.ac.rs/handle/123456789/4726]
dc.identifier.doi10.1016/j.jelechem.2020.114324
dc.identifier.scopus2-s2.0-85086820704
dc.identifier.wos000572073600001
dc.type.versionpublishedVersion


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