Приказ основних података о документу

dc.creatorRajilić-Stojanović, Mirjana
dc.creatorFigueiredo, Ceu
dc.creatorSmet, Annemieke
dc.creatorHansen, Richard
dc.creatorKupcinskas, Juozas
dc.creatorRokkas, Theo
dc.creatorAndersen, Leif
dc.creatorMachado, Jose C.
dc.creatorIaniro, Gianluca
dc.creatorGasbarrini, Antonio
dc.creatorLeja, Marcis
dc.creatorGisbert, Javier P.
dc.creatorHold, Georgina L.
dc.date.accessioned2021-03-10T14:21:26Z
dc.date.available2021-03-10T14:21:26Z
dc.date.issued2020
dc.identifier.issn0269-2813
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4478
dc.description.abstractBackground Helicobacter pylori is the most infamous constituent of the gastric microbiota and its presence is the strongest risk factor for gastric cancer and other gastroduodenal diseases. Although historically the healthy stomach was considered a sterile organ, we now know it is colonised with a complex microbiota. However, its role in health and disease is not well understood. Aim To systematically explore the literature on the gastric microbiota in health and disease as well as the gut microbiota after bariatric surgery. Methods A systematic search of online bibliographic databases MEDLINE/EMBASE was performed between 1966 and February 2019 with screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomised controlled trials, cohort studies and observational studies were included if they reported next-generation sequencing derived microbiota analysis on gastric aspirate/tissue or stool samples (bariatric surgical outcomes). Results Sixty-five papers were eligible for inclusion. With the exception of H pylori-induced conditions, overarching gastric microbiota signatures of health or disease could not be determined. Gastric carcinogenesis induces a progressively altered microbiota with an enrichment of oral and intestinal taxa as well as significant changes in host gastric mucin expression. Proton pump inhibitors usage increases gastric microbiota richness. Bariatric surgery is associated with an increase in potentially pathogenic proteobacterial species in patient stool samples. Conclusion While H pylori remains the single most important risk factor for gastric disease, its capacity to shape the collective gastric microbiota remains to be fully elucidated. Further studies are needed to explore the intricate host/microbial and microbial/microbial interplay.en
dc.publisherWiley, Hoboken
dc.rightsrestrictedAccess
dc.sourceAlimentary Pharmacology & Therapeutics
dc.titleSystematic review: gastric microbiota in health and diseaseen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage602
dc.citation.issue6
dc.citation.other51(6): 582-602
dc.citation.rankaM21
dc.citation.spage582
dc.citation.volume51
dc.identifier.doi10.1111/apt.15650
dc.identifier.pmid32056247
dc.identifier.scopus2-s2.0-85079728677
dc.identifier.wos000513171200001
dc.type.versionpublishedVersion


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Приказ основних података о документу