Приказ основних података о документу

dc.creatorTadic, Vanja M.
dc.creatorZugic, Ana
dc.creatorMartinovic, Milica
dc.creatorStankovic, Milica
dc.creatorMaksimović, Svetolik
dc.creatorFrank, Almut
dc.creatorNesic, Ivana
dc.date.accessioned2022-03-04T11:18:11Z
dc.date.available2022-03-04T11:18:11Z
dc.date.issued2021
dc.identifier.issn1999-4923
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4821
dc.description.abstractImmortelle, as rich source of chlorogenic acid and the phloroglucinol alpha-pyrone compound arzanol, possesses anti-inflammatory and antioxidant properties, affects cell regeneration, and has positive effect on many skin conditions. Hemp oil, characterized by a favorable omega-6 to omega-3 ratio, as well as an abundance of essential fatty acids and vitamin E, participates in immunoregulation and also act as an anti-inflammatory. In the present study, we examined the effect on the skin of creams and emulgels with immortelle extract and hemp oil, by comparing them to placebo samples and a non-treated control. A long-term in vivo study of biophysical skin characteristics, which lasted for 30 days, was conducted on 25 healthy human volunteers. Measured parameters were electrical capacitance of the stratum corneum, trans-epidermal water loss (TEWL), and skin pH and erythema index. Further, a sensory study was carried out in which the panelists had to choose descriptive terms for sensory attributes in questionnaire. The results showed that application of all preparations led to increase of skin hydration and TEWL reduction, while the skin was not irritated, and its normal pH was not disrupted. This study also showed importance of the carrier. Not only were emulgels described by panelists as preparations with better sensory properties, there was a significant difference between the skin hydration effect of emulgel with immortelle extract and hemp oil compared to the placebo emulgel, which was not the case with creams. Such findings indicated enhanced delivery of herbal active substances from emulgel compared to the cream.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200003/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200113/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePharmaceutics
dc.subjectimmortelleen
dc.subjecthemp oilen
dc.subjectemulgelen
dc.subjectcreamen
dc.subjectskin bioengineeringen
dc.titleEnhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)en
dc.typearticle
dc.rights.licenseBY
dc.citation.issue11
dc.citation.other13(11): -
dc.citation.rankM21
dc.citation.volume13
dc.identifier.doi10.3390/pharmaceutics13111919
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/7745/Enhanced_skin_performance_pub_2021.pdf
dc.identifier.pmid34834334
dc.identifier.scopus2-s2.0-85119611036
dc.identifier.wos000723759700001
dc.type.versionpublishedVersion


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Приказ основних података о документу