An Investigation into Mechanical Properties and Printability of Potential Substrates for Inkjet Printing of Orodispersible Films
Аутори
Turkovic, ErnaVasiljevic, Ivana
Draskovic, Milica
Obradović, Nataša
Vasiljevic, Dragana
Parojcic, Jelena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Inkjet printing is novel approach in drug manufacturing that enables dispensing precise volumes of ink onto substrates. Optimal substrate properties including suitable mechanical characteristic are recognized as crucial to achieve desired dosage form performance upon administration. Identification of relevant quality attributes and their quantification is subject of intensive scientific research. The aim of this work was to explore applicability of different materials as printing substrates and explore contribution of the investigated substrate properties to its printability. Substrates were characterized with regards to uniformity, porosity, disintegration time, mechanical properties and drug dissolution. Experimentally obtained values were mathematically transformed and the obtained results were presented as relevant radar charts. It was shown that structurally different substrates may be employed for orodispersible films inkjet printing. Main disadvantage of single-polymer films was... low drug load, and their printability was dependent on film flexibility and mechanical strength. Structured orodispersible film templates exhibited favorable mechanical properties and drug load capacity. Wafer edible sheets were characterized with high mechanical resistance and brittleness which somewhat diminished printability, but did not hinder high drug load. Obtained results provide insight into application of different materials as printing substrates and contribute to understanding of substrate properties which can affect printability.
Кључне речи:
inkjet printing / printing substrates / mechanical properties / orodispersible films / structured orodispersible film templates / wafer edible sheetsИзвор:
Pharmaceutics, 2021, 13, 4Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/pharmaceutics13040468
ISSN: 1999-4923
PubMed: 33808374
WoS: 000643502300001
Scopus: 2-s2.0-85103891211
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Turkovic, Erna AU - Vasiljevic, Ivana AU - Draskovic, Milica AU - Obradović, Nataša AU - Vasiljevic, Dragana AU - Parojcic, Jelena PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4881 AB - Inkjet printing is novel approach in drug manufacturing that enables dispensing precise volumes of ink onto substrates. Optimal substrate properties including suitable mechanical characteristic are recognized as crucial to achieve desired dosage form performance upon administration. Identification of relevant quality attributes and their quantification is subject of intensive scientific research. The aim of this work was to explore applicability of different materials as printing substrates and explore contribution of the investigated substrate properties to its printability. Substrates were characterized with regards to uniformity, porosity, disintegration time, mechanical properties and drug dissolution. Experimentally obtained values were mathematically transformed and the obtained results were presented as relevant radar charts. It was shown that structurally different substrates may be employed for orodispersible films inkjet printing. Main disadvantage of single-polymer films was low drug load, and their printability was dependent on film flexibility and mechanical strength. Structured orodispersible film templates exhibited favorable mechanical properties and drug load capacity. Wafer edible sheets were characterized with high mechanical resistance and brittleness which somewhat diminished printability, but did not hinder high drug load. Obtained results provide insight into application of different materials as printing substrates and contribute to understanding of substrate properties which can affect printability. T2 - Pharmaceutics T1 - An Investigation into Mechanical Properties and Printability of Potential Substrates for Inkjet Printing of Orodispersible Films IS - 4 VL - 13 DO - 10.3390/pharmaceutics13040468 ER -
@article{ author = "Turkovic, Erna and Vasiljevic, Ivana and Draskovic, Milica and Obradović, Nataša and Vasiljevic, Dragana and Parojcic, Jelena", year = "2021", abstract = "Inkjet printing is novel approach in drug manufacturing that enables dispensing precise volumes of ink onto substrates. Optimal substrate properties including suitable mechanical characteristic are recognized as crucial to achieve desired dosage form performance upon administration. Identification of relevant quality attributes and their quantification is subject of intensive scientific research. The aim of this work was to explore applicability of different materials as printing substrates and explore contribution of the investigated substrate properties to its printability. Substrates were characterized with regards to uniformity, porosity, disintegration time, mechanical properties and drug dissolution. Experimentally obtained values were mathematically transformed and the obtained results were presented as relevant radar charts. It was shown that structurally different substrates may be employed for orodispersible films inkjet printing. Main disadvantage of single-polymer films was low drug load, and their printability was dependent on film flexibility and mechanical strength. Structured orodispersible film templates exhibited favorable mechanical properties and drug load capacity. Wafer edible sheets were characterized with high mechanical resistance and brittleness which somewhat diminished printability, but did not hinder high drug load. Obtained results provide insight into application of different materials as printing substrates and contribute to understanding of substrate properties which can affect printability.", journal = "Pharmaceutics", title = "An Investigation into Mechanical Properties and Printability of Potential Substrates for Inkjet Printing of Orodispersible Films", number = "4", volume = "13", doi = "10.3390/pharmaceutics13040468" }
Turkovic, E., Vasiljevic, I., Draskovic, M., Obradović, N., Vasiljevic, D.,& Parojcic, J.. (2021). An Investigation into Mechanical Properties and Printability of Potential Substrates for Inkjet Printing of Orodispersible Films. in Pharmaceutics, 13(4). https://doi.org/10.3390/pharmaceutics13040468
Turkovic E, Vasiljevic I, Draskovic M, Obradović N, Vasiljevic D, Parojcic J. An Investigation into Mechanical Properties and Printability of Potential Substrates for Inkjet Printing of Orodispersible Films. in Pharmaceutics. 2021;13(4). doi:10.3390/pharmaceutics13040468 .
Turkovic, Erna, Vasiljevic, Ivana, Draskovic, Milica, Obradović, Nataša, Vasiljevic, Dragana, Parojcic, Jelena, "An Investigation into Mechanical Properties and Printability of Potential Substrates for Inkjet Printing of Orodispersible Films" in Pharmaceutics, 13, no. 4 (2021), https://doi.org/10.3390/pharmaceutics13040468 . .