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In vitro evaluation of the controlled release of antibiotics from liposomes

In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma

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2003
498.pdf (578.5Kb)
Authors
Boltić, Zorana
Petkovska, Menka
Obradović, Bojana
Nedović, Viktor
Bugarski, Branko
Article (Published version)
Metadata
Show full item record
Abstract
Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.
Keywords:
Controlled release / Diffusion / Liposomes / Membrane module / Modeling
Source:
Chemical Industry & Chemical Engineering Quarterly, 2003, 9, 4, 589-595
Publisher:
  • Association of the Chemical Engineers of Serbia

DOI: 10.2298/HEMIND0312589B

ISSN: 1451-9372

PubMed:

Scopus: 2-s2.0-85034592650
[ Google Scholar ]
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/501
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Boltić, Zorana
AU  - Petkovska, Menka
AU  - Obradović, Bojana
AU  - Nedović, Viktor
AU  - Bugarski, Branko
PY  - 2003
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/501
AB  - Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - In vitro evaluation of the controlled release of antibiotics from liposomes
T1  - In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma
EP  - 595
IS  - 4
SP  - 589
VL  - 9
DO  - 10.2298/HEMIND0312589B
UR  - conv_7055
ER  - 
@article{
author = "Boltić, Zorana and Petkovska, Menka and Obradović, Bojana and Nedović, Viktor and Bugarski, Branko",
year = "2003",
abstract = "Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "In vitro evaluation of the controlled release of antibiotics from liposomes, In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma",
pages = "595-589",
number = "4",
volume = "9",
doi = "10.2298/HEMIND0312589B",
url = "conv_7055"
}
Boltić, Z., Petkovska, M., Obradović, B., Nedović, V.,& Bugarski, B.. (2003). In vitro evaluation of the controlled release of antibiotics from liposomes. in Chemical Industry & Chemical Engineering Quarterly
Association of the Chemical Engineers of Serbia., 9(4), 589-595.
https://doi.org/10.2298/HEMIND0312589B
conv_7055
Boltić Z, Petkovska M, Obradović B, Nedović V, Bugarski B. In vitro evaluation of the controlled release of antibiotics from liposomes. in Chemical Industry & Chemical Engineering Quarterly. 2003;9(4):589-595.
doi:10.2298/HEMIND0312589B
conv_7055 .
Boltić, Zorana, Petkovska, Menka, Obradović, Bojana, Nedović, Viktor, Bugarski, Branko, "In vitro evaluation of the controlled release of antibiotics from liposomes" in Chemical Industry & Chemical Engineering Quarterly, 9, no. 4 (2003):589-595,
https://doi.org/10.2298/HEMIND0312589B .,
conv_7055 .

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