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dc.creatorPajić-Lijaković, Ivana
dc.creatorBugarski, Branko
dc.creatorObradović, Bojana
dc.creatorPlavšić, Milenko B.
dc.creatorBugarski, Diana
dc.date.accessioned2021-03-10T10:08:52Z
dc.date.available2021-03-10T10:08:52Z
dc.date.issued2003
dc.identifier.issn0098-6445
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/560
dc.description.abstractDevelopment of lipid-based fine particles as potential drug carriers requires detailed investigation of possible effects of these carriers on rheological properties of blood. In this study, we have investigated the influence of dynamic conditions on aggregate formation and stability in dispersions of lipid-based fine particles in whole blood under in vitro conditions. Rheological parameters of two concentrations of liposome dispersion and two concentrations of lipid emulsion in blood were studied by assessing shear stress/shear rate relationships. The magnitude of attractive interactions between aggregates and/or particles, A, and the effective-to-real volume fraction of particles, phi(f)/phi(p) , were estimated for rheological quantification of lipid-based fine particles-blood interactions and aggregate stability. Addition of lipid-based particles induced aggregate formation in blood, which was more pronounced at higher concentrations of lipid-based fine particles. Furthermore, larger and more stable aggregates were formed in liposome dispersions as compared to lipid emulsions in blood.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.rightsrestrictedAccess
dc.sourceChemical Engineering Communications
dc.subjectblood rheologyen
dc.subjectlipid-based fine particlesen
dc.subjectaggregation in blooden
dc.titleExamination of rheological properties of fine particles as carriers for controlled drug releaseen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage93
dc.citation.issue1
dc.citation.other190(1): 83-93
dc.citation.rankM23
dc.citation.spage83
dc.citation.volume190
dc.identifier.doi10.1080/00986440302091
dc.identifier.scopus2-s2.0-0242274328
dc.identifier.wos000180134000005
dc.type.versionpublishedVersion


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Приказ основних података о документу