Monte Carlo simulation of health risk from cadmium, lead, and nickel in cigarettes
Само за регистроване кориснике
2023
Аутори
Lučić, MilicaMomčilović, Milan
Marković, Jelena
Jović, Mihajlo
Smiciklas, Ivana
Onjia, Antonije
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The human health risks of cadmium (Cd), lead (Pb), and nickel
(Ni) in fifty regular and slim cigarette brands available in the
Serbian market were evaluated. Distributions on per-cigarette
basis concentrations of these metals, as determined by graphite
furnace atomic absorption spectrometry, were used as inputs in
the probabilistic risk assessment. The contents of these metals in
cigarettes varied significantly. Larger quantities of the studied
metals were observed in regular cigarettes than in slim cigarettes,
but the concentration levels per cigarette tobacco mass were
higher in slim cigarettes. The metal concentrations in counterfeit
cigarettes were marginally higher than those in authentic brands.
Based on the mean concentrations, Pb was the most abundant
toxic metal, followed by Ni and Cd. The calculated values of the
cumulative hazard index (HI) and incremental lifetime cancer risk
(ILCR) indicated a low noncarcinogenic risk and low but not negligible
carcinogenic ...risk from Cd, Pb, and Ni. The mean HI and ILCR
values obtained using probabilistic and deterministic approaches
were similar. A Monte Carlo simulation was employed to minimize
the uncertainty of health risk estimation. The sensitivity analysis
revealed that the most influential factor was cigarette mass followed
by Cd content.
Кључне речи:
ILCR / toxic metals / noncarcinogenic risk / tobacco / sensitivity analysis; / distributionИзвор:
Toxicological and Environmental Chemistry, 2023, 104, 2Издавач:
- Taylor & Francis
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-MESTD-inst-2020-200135)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
Институција/група
Inovacioni centarTY - JOUR AU - Lučić, Milica AU - Momčilović, Milan AU - Marković, Jelena AU - Jović, Mihajlo AU - Smiciklas, Ivana AU - Onjia, Antonije PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6329 AB - The human health risks of cadmium (Cd), lead (Pb), and nickel (Ni) in fifty regular and slim cigarette brands available in the Serbian market were evaluated. Distributions on per-cigarette basis concentrations of these metals, as determined by graphite furnace atomic absorption spectrometry, were used as inputs in the probabilistic risk assessment. The contents of these metals in cigarettes varied significantly. Larger quantities of the studied metals were observed in regular cigarettes than in slim cigarettes, but the concentration levels per cigarette tobacco mass were higher in slim cigarettes. The metal concentrations in counterfeit cigarettes were marginally higher than those in authentic brands. Based on the mean concentrations, Pb was the most abundant toxic metal, followed by Ni and Cd. The calculated values of the cumulative hazard index (HI) and incremental lifetime cancer risk (ILCR) indicated a low noncarcinogenic risk and low but not negligible carcinogenic risk from Cd, Pb, and Ni. The mean HI and ILCR values obtained using probabilistic and deterministic approaches were similar. A Monte Carlo simulation was employed to minimize the uncertainty of health risk estimation. The sensitivity analysis revealed that the most influential factor was cigarette mass followed by Cd content. PB - Taylor & Francis T2 - Toxicological and Environmental Chemistry T1 - Monte Carlo simulation of health risk from cadmium, lead, and nickel in cigarettes IS - 2 VL - 104 DO - 10.1080/02772248.2023.2177291 ER -
@article{ author = "Lučić, Milica and Momčilović, Milan and Marković, Jelena and Jović, Mihajlo and Smiciklas, Ivana and Onjia, Antonije", year = "2023", abstract = "The human health risks of cadmium (Cd), lead (Pb), and nickel (Ni) in fifty regular and slim cigarette brands available in the Serbian market were evaluated. Distributions on per-cigarette basis concentrations of these metals, as determined by graphite furnace atomic absorption spectrometry, were used as inputs in the probabilistic risk assessment. The contents of these metals in cigarettes varied significantly. Larger quantities of the studied metals were observed in regular cigarettes than in slim cigarettes, but the concentration levels per cigarette tobacco mass were higher in slim cigarettes. The metal concentrations in counterfeit cigarettes were marginally higher than those in authentic brands. Based on the mean concentrations, Pb was the most abundant toxic metal, followed by Ni and Cd. The calculated values of the cumulative hazard index (HI) and incremental lifetime cancer risk (ILCR) indicated a low noncarcinogenic risk and low but not negligible carcinogenic risk from Cd, Pb, and Ni. The mean HI and ILCR values obtained using probabilistic and deterministic approaches were similar. A Monte Carlo simulation was employed to minimize the uncertainty of health risk estimation. The sensitivity analysis revealed that the most influential factor was cigarette mass followed by Cd content.", publisher = "Taylor & Francis", journal = "Toxicological and Environmental Chemistry", title = "Monte Carlo simulation of health risk from cadmium, lead, and nickel in cigarettes", number = "2", volume = "104", doi = "10.1080/02772248.2023.2177291" }
Lučić, M., Momčilović, M., Marković, J., Jović, M., Smiciklas, I.,& Onjia, A.. (2023). Monte Carlo simulation of health risk from cadmium, lead, and nickel in cigarettes. in Toxicological and Environmental Chemistry Taylor & Francis., 104(2). https://doi.org/10.1080/02772248.2023.2177291
Lučić M, Momčilović M, Marković J, Jović M, Smiciklas I, Onjia A. Monte Carlo simulation of health risk from cadmium, lead, and nickel in cigarettes. in Toxicological and Environmental Chemistry. 2023;104(2). doi:10.1080/02772248.2023.2177291 .
Lučić, Milica, Momčilović, Milan, Marković, Jelena, Jović, Mihajlo, Smiciklas, Ivana, Onjia, Antonije, "Monte Carlo simulation of health risk from cadmium, lead, and nickel in cigarettes" in Toxicological and Environmental Chemistry, 104, no. 2 (2023), https://doi.org/10.1080/02772248.2023.2177291 . .