Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine
Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina
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Modern society are faced with lot of challenges in the treatment of many diseases, especially
with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main
goals which researchers are aiming. One of the good approaches can be drug delivery systems.
Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release
can be quite challenging. Present study is focused to improve drug delivery system based on
hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble
caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of
crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-
4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in
two environments which simulate human stomach and intestines. It is also investigated how the
change in the encapsulated caff...eine weight and the addition of liposomes with encapsulated caffeine,
affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results
show that controlled release of caffeine is improved, therefore overall therapy can be enhanced.
Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena... količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.
Keywords:
pH sensitive hydrogels / casein / liposomes / controlled release / poorly watersoluble drugs / pH osetljivi hidrogelovi / kazein / lipozomi / kontrolisano otpuštanje / slabovodorastvorni lekoviSource:
Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac, 2023, 181-187Publisher:
- Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
Institution/Community
Inovacioni centarTY - CONF AU - Marković, Maja D. AU - Spasojević, Pavle M. AU - Savić, Sanja I. AU - Pantić, Olga J. AU - Panić, Vesna V. PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6737 AB - Modern society are faced with lot of challenges in the treatment of many diseases, especially with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main goals which researchers are aiming. One of the good approaches can be drug delivery systems. Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release can be quite challenging. Present study is focused to improve drug delivery system based on hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N- 4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in two environments which simulate human stomach and intestines. It is also investigated how the change in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine, affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results show that controlled release of caffeine is improved, therefore overall therapy can be enhanced. AB - Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju. PB - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku C3 - Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac T1 - Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine T1 - Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina EP - 187 SP - 181 UR - https://hdl.handle.net/21.15107/rcub_technorep_6737 ER -
@conference{ author = "Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Pantić, Olga J. and Panić, Vesna V.", year = "2023", abstract = "Modern society are faced with lot of challenges in the treatment of many diseases, especially with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main goals which researchers are aiming. One of the good approaches can be drug delivery systems. Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release can be quite challenging. Present study is focused to improve drug delivery system based on hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N- 4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in two environments which simulate human stomach and intestines. It is also investigated how the change in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine, affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results show that controlled release of caffeine is improved, therefore overall therapy can be enhanced., Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.", publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku", journal = "Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac", title = "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine, Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina", pages = "187-181", url = "https://hdl.handle.net/21.15107/rcub_technorep_6737" }
Marković, M. D., Spasojević, P. M., Savić, S. I., Pantić, O. J.,& Panić, V. V.. (2023). Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 181-187. https://hdl.handle.net/21.15107/rcub_technorep_6737
Marković MD, Spasojević PM, Savić SI, Pantić OJ, Panić VV. Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac. 2023;:181-187. https://hdl.handle.net/21.15107/rcub_technorep_6737 .
Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Pantić, Olga J., Panić, Vesna V., "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine" in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac (2023):181-187, https://hdl.handle.net/21.15107/rcub_technorep_6737 .