Sinteza i karakterizacija kompleksa tributilkalaja(IV) sa 2-(4- hidroksi-2-oksohinolinil)propanskom kiselinom

Abstract

U datom radu opisana je sinteza 2-(4-hidroksi-2-oksohinolinil)propanske kiseline i njenog kompleksa tributilkalaja(IV). Ligand prekursor je dobijen hidrolizom metil-estra sintetisanog u reakciji između 4-hidroksi-2-hinolona i metil-2-bromopropanoata. U reakciji deprotonovanog liganda i ekvimolarne količine Bu3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Ligand prekursor i odgovarajući kompleks tributilkalaja(IV) biće testirani na antitumorsku aktivnost prema raznim tumorskim ćelijskim linijama.

Synthesis of 2-(4-methyl-2-oxoquinolinyl)propanoic acid and its tributyltin(IV) complex has been performed. The ligand precursor has been obtained by the hydrolysis of methyl ester synthesized in the reaction between 4-hydroxy-2-quinolone and methyl 2- bromopropanoate. In the reaction of deprotonated ligand with equimolar amount of Bu3SnCl, the desired complex was precipitated as a white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of ligand precursor and corresponding tributyltin(IV) complex will be focused on examining their antitumor activity against various cancer cell lines.